TY - JOUR
T1 - Circulating cytomegalic endothelial cells are associated with high human cytomegalovirus (HCMV) load in AIDS patients with late-stage disseminated HCMV disease
AU - Gerna, Giuseppe
AU - Zavattoni, Maurizio
AU - Baldanti, Fausto
AU - Furione, Milena
AU - Chezzi, Lucia
AU - Revello, M. Grazia
AU - Percivalle, Elena
PY - 1998/5
Y1 - 1998/5
N2 - The prevalence of circulating cytomegalic endothelial cells, detected currently by the pp65-antigenemia assay and described previously in blood of transplanted and AIDS patients with disseminated human cytomegalovirus (HCMV) infection, was found to be 2.9% in the AIDS population and 6.5% in the fraction of the AIDS population with HCMV in blood. Cytomegalic endothelial cells increased to 39.7% and 48.4%, respectively, in AIDS patients with very high levels of antigenemia and viremia, while an end organ disease reached an incidence of 76.4%. Positive and negative predictive values of cytomegalic endothelial cell detection for diagnosis of HCMV end organ disease were 73.1% and 21.4% with antigenemia levels >1,000, respectively. On the other hand, in a selected group of 38 cytomegalic endothelial cell-positive AIDS patients with
AB - The prevalence of circulating cytomegalic endothelial cells, detected currently by the pp65-antigenemia assay and described previously in blood of transplanted and AIDS patients with disseminated human cytomegalovirus (HCMV) infection, was found to be 2.9% in the AIDS population and 6.5% in the fraction of the AIDS population with HCMV in blood. Cytomegalic endothelial cells increased to 39.7% and 48.4%, respectively, in AIDS patients with very high levels of antigenemia and viremia, while an end organ disease reached an incidence of 76.4%. Positive and negative predictive values of cytomegalic endothelial cell detection for diagnosis of HCMV end organ disease were 73.1% and 21.4% with antigenemia levels >1,000, respectively. On the other hand, in a selected group of 38 cytomegalic endothelial cell-positive AIDS patients with
KW - Antiviral treatment
KW - HCMV drug-resistant strains
KW - HCMV end organ disease
KW - HCMV leukoDNAemia
KW - HCMV viremia
KW - Pp65-antigenemia
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U2 - 10.1002/(SICI)1096-9071(199805)55:1<64::AID-JMV11>3.0.CO;2-#
DO - 10.1002/(SICI)1096-9071(199805)55:1<64::AID-JMV11>3.0.CO;2-#
M3 - Article
C2 - 9580888
VL - 55
SP - 64
EP - 74
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 1
ER -