Circulating cytomegalic endothelial cells are associated with high human cytomegalovirus (HCMV) load in AIDS patients with late-stage disseminated HCMV disease

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Abstract

The prevalence of circulating cytomegalic endothelial cells, detected currently by the pp65-antigenemia assay and described previously in blood of transplanted and AIDS patients with disseminated human cytomegalovirus (HCMV) infection, was found to be 2.9% in the AIDS population and 6.5% in the fraction of the AIDS population with HCMV in blood. Cytomegalic endothelial cells increased to 39.7% and 48.4%, respectively, in AIDS patients with very high levels of antigenemia and viremia, while an end organ disease reached an incidence of 76.4%. Positive and negative predictive values of cytomegalic endothelial cell detection for diagnosis of HCMV end organ disease were 73.1% and 21.4% with antigenemia levels >1,000, respectively. On the other hand, in a selected group of 38 cytomegalic endothelial cell-positive AIDS patients with

Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalJournal of Medical Virology
Volume55
Issue number1
DOIs
Publication statusPublished - May 1998

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Cytomegalovirus
Acquired Immunodeficiency Syndrome
Endothelial Cells
Viremia
Cytomegalovirus Infections
Population
Incidence

Keywords

  • Antiviral treatment
  • HCMV drug-resistant strains
  • HCMV end organ disease
  • HCMV leukoDNAemia
  • HCMV viremia
  • Pp65-antigenemia

ASJC Scopus subject areas

  • Virology

Cite this

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title = "Circulating cytomegalic endothelial cells are associated with high human cytomegalovirus (HCMV) load in AIDS patients with late-stage disseminated HCMV disease",
abstract = "The prevalence of circulating cytomegalic endothelial cells, detected currently by the pp65-antigenemia assay and described previously in blood of transplanted and AIDS patients with disseminated human cytomegalovirus (HCMV) infection, was found to be 2.9{\%} in the AIDS population and 6.5{\%} in the fraction of the AIDS population with HCMV in blood. Cytomegalic endothelial cells increased to 39.7{\%} and 48.4{\%}, respectively, in AIDS patients with very high levels of antigenemia and viremia, while an end organ disease reached an incidence of 76.4{\%}. Positive and negative predictive values of cytomegalic endothelial cell detection for diagnosis of HCMV end organ disease were 73.1{\%} and 21.4{\%} with antigenemia levels >1,000, respectively. On the other hand, in a selected group of 38 cytomegalic endothelial cell-positive AIDS patients with",
keywords = "Antiviral treatment, HCMV drug-resistant strains, HCMV end organ disease, HCMV leukoDNAemia, HCMV viremia, Pp65-antigenemia",
author = "Giuseppe Gerna and Maurizio Zavattoni and Fausto Baldanti and Milena Furione and Lucia Chezzi and Revello, {M. Grazia} and Elena Percivalle",
year = "1998",
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doi = "10.1002/(SICI)1096-9071(199805)55:1<64::AID-JMV11>3.0.CO;2-#",
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AU - Gerna, Giuseppe

AU - Zavattoni, Maurizio

AU - Baldanti, Fausto

AU - Furione, Milena

AU - Chezzi, Lucia

AU - Revello, M. Grazia

AU - Percivalle, Elena

PY - 1998/5

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N2 - The prevalence of circulating cytomegalic endothelial cells, detected currently by the pp65-antigenemia assay and described previously in blood of transplanted and AIDS patients with disseminated human cytomegalovirus (HCMV) infection, was found to be 2.9% in the AIDS population and 6.5% in the fraction of the AIDS population with HCMV in blood. Cytomegalic endothelial cells increased to 39.7% and 48.4%, respectively, in AIDS patients with very high levels of antigenemia and viremia, while an end organ disease reached an incidence of 76.4%. Positive and negative predictive values of cytomegalic endothelial cell detection for diagnosis of HCMV end organ disease were 73.1% and 21.4% with antigenemia levels >1,000, respectively. On the other hand, in a selected group of 38 cytomegalic endothelial cell-positive AIDS patients with

AB - The prevalence of circulating cytomegalic endothelial cells, detected currently by the pp65-antigenemia assay and described previously in blood of transplanted and AIDS patients with disseminated human cytomegalovirus (HCMV) infection, was found to be 2.9% in the AIDS population and 6.5% in the fraction of the AIDS population with HCMV in blood. Cytomegalic endothelial cells increased to 39.7% and 48.4%, respectively, in AIDS patients with very high levels of antigenemia and viremia, while an end organ disease reached an incidence of 76.4%. Positive and negative predictive values of cytomegalic endothelial cell detection for diagnosis of HCMV end organ disease were 73.1% and 21.4% with antigenemia levels >1,000, respectively. On the other hand, in a selected group of 38 cytomegalic endothelial cell-positive AIDS patients with

KW - Antiviral treatment

KW - HCMV drug-resistant strains

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KW - Pp65-antigenemia

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