Circulating cytomegalic endothelial cells are associated with high human cytomegalovirus (HCMV) load in AIDS patients with late-stage disseminated HCMV disease

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Abstract

The prevalence of circulating cytomegalic endothelial cells, detected currently by the pp65-antigenemia assay and described previously in blood of transplanted and AIDS patients with disseminated human cytomegalovirus (HCMV) infection, was found to be 2.9% in the AIDS population and 6.5% in the fraction of the AIDS population with HCMV in blood. Cytomegalic endothelial cells increased to 39.7% and 48.4%, respectively, in AIDS patients with very high levels of antigenemia and viremia, while an end organ disease reached an incidence of 76.4%. Positive and negative predictive values of cytomegalic endothelial cell detection for diagnosis of HCMV end organ disease were 73.1% and 21.4% with antigenemia levels >1,000, respectively. On the other hand, in a selected group of 38 cytomegalic endothelial cell-positive AIDS patients with

Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalJournal of Medical Virology
Volume55
Issue number1
DOIs
Publication statusPublished - May 1998

Keywords

  • Antiviral treatment
  • HCMV drug-resistant strains
  • HCMV end organ disease
  • HCMV leukoDNAemia
  • HCMV viremia
  • Pp65-antigenemia

ASJC Scopus subject areas

  • Virology

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