Circulating dendritic cells are severely decreased in idiopathic pulmonary fibrosis with a potential value for prognosis prediction

Domenico Galati, Serena Zanotta, Giorgio Emanuele Polistina, Antonietta Coppola, Ludovica Capitelli, Marialuisa Bocchino

Research output: Contribution to journalArticle

Abstract

Dendritic cells (DCs) accumulate in the lung of patients affected by idiopathic pulmonary fibrosis (IPF). We measured the frequencies of circulating conventional CD1c + and CD141+ cells (namely, cDC2 and cDC1) and of plasmacytoid CD303+ DCs in a cohort of 60 therapy naive IPF patients by flow cytometry. Peripheral levels of reactive oxygen species (ROS) and of pro-inflammatory and Th1/Th2 polarizing cytokines were also analyzed. All blood DC subtypes were significantly reduced in IPF patients in comparison to age- and sex-matched controls, while ROS and interleukin (IL-6) levels were augmented. IL-6 expression increased along with disease severity, according to the gender-age-physiology index, and correlated with the frequency of cDC2. IL-6 and cDC2 were not influenced by anti-fibrotic therapies but were associated with a reduced survival, the latter being an independent predictive biomarker of worse prognosis. Deciphering the role of DCs in IPF might provide information on disease pathogenesis and clinical behavior.

Original languageEnglish
Article number108454
JournalClinical Immunology
Volume215
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Dendritic cells
  • Flow cytometry
  • Idiopathic pulmonary fibrosis
  • Interleukin-6
  • Oxidative burst

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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