Circulating dopmaine in Raynaud's phenomenon

B. Marasini, M. L. Biondi, A. Agostoni

Research output: Contribution to journalArticle

Abstract

Plasma free and conjugated and intraplatelet free dopamine, norepinephrine, and epinephrine levels were determined by high-performance liquid chromatography coupled with electrochemical detection for 20 subjects with Raynaud's phenomenon of various etiologies. Circulating free dopamine and epinephrine were significantly lower in Raynaud's patients than in controls (dopamine 26.0 ± 13.6 vs 56.3 ± 39.6 pg/ml, p <0.005; epinephrine 25.8 ± 16.9 vs 56.9 ± 40.9 pg/ml, p <0.005), while the corresponding conjugated forms in plasma and the intraplatelet contents were within normal limits. There were no abnormalities in plasma free, conjugated, or intraplatelet free norepinephrine. All of the levels were independent of the etiology, the duration, and the severity of the disease. The reduced plasma levels of free dopamine and epinephrine might be due to impaired adrenal release in response to some kinds of sympathetic stimulation or to rapid tissue uptake and peripheral metabolism. A possible role for a post-ischemic dopaminergic vasodilating system is discussed.

Original languageEnglish
Pages (from-to)878-882
Number of pages5
JournalAngiology
Volume38
Issue number12
Publication statusPublished - 1987

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Raynaud Disease
Epinephrine
Dopamine
Norepinephrine
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Marasini, B., Biondi, M. L., & Agostoni, A. (1987). Circulating dopmaine in Raynaud's phenomenon. Angiology, 38(12), 878-882.

Circulating dopmaine in Raynaud's phenomenon. / Marasini, B.; Biondi, M. L.; Agostoni, A.

In: Angiology, Vol. 38, No. 12, 1987, p. 878-882.

Research output: Contribution to journalArticle

Marasini, B, Biondi, ML & Agostoni, A 1987, 'Circulating dopmaine in Raynaud's phenomenon', Angiology, vol. 38, no. 12, pp. 878-882.
Marasini B, Biondi ML, Agostoni A. Circulating dopmaine in Raynaud's phenomenon. Angiology. 1987;38(12):878-882.
Marasini, B. ; Biondi, M. L. ; Agostoni, A. / Circulating dopmaine in Raynaud's phenomenon. In: Angiology. 1987 ; Vol. 38, No. 12. pp. 878-882.
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