Circulating endothelin-1 levels in patients with "a frigore" vascular acrosyndromes

R. A. Mangiafico, L. S. Malatino, R. S. Spada, M. Santonocito

Research output: Contribution to journalArticlepeer-review


The present study was designed to examine the role of endothelin-1 (ET-1), an endothelium-derived potent long-acting vasoconstrictor peptide, in vascular acrosyndromes with hypersensitivity to cold. Plasma ET-1 concentration was measured, before and after cold test, in 12 subjects with "a frigore" vascular acrosyndromes (9 females and 3 males, age range 17-59 years), of whom 6 were with primary Raynaud's phenomenon and 6 with essential acrocyanosis, and in 6 controls (5 females and 1 male, age range 21-37 years). Cold stimulation was performed by immersion of one hand into a water bath at 13°C for 5 minutes. Blood samples were simultaneously drawn from an antecubital vein in the cooled side and in the contralateral arm at baseline, at the stop of cooling, at 10 and 90 minutes from the beginning of the cold challenge. Mean (±SD) baseline ET-1 plasma levels, as measured by radioimmunoassay, were higher in patients with "a frigore" vascular acrosyndromes (4.8±0.3 pmol/l) than in control subjects (1.9±0.1 pmol/l, p

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalPanminerva Medica
Issue number4
Publication statusPublished - 1996


  • Cold
  • Endothelin-1
  • Vascular acrosyndromes

ASJC Scopus subject areas

  • Medicine(all)


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