Circulating estradiol and mortality in men with systolic chronic heart failure

Ewa A. Jankowska, Piotr Rozentryt, Beata Ponikowska, Oliver Hartmann, Dorota Kustrzycka-Kratochwil, Krzysztof Reczuch, Jolanta Nowak, Ludmila Borodulin-Nadzieja, Lech Polonski, Waldemar Banasiak, Philip A. Poole-Wilson, Stefan D. Anker, Piotr Ponikowski

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Androgen deficiency is common in men with chronic heart failure (HF) and is associated with increased morbidity and mortality. Estrogens are formed by the aromatization of androgens; therefore, abnormal estrogen metabolism would be anticipated in HF. Objective: To examine the relationship between serum concentration of estradiol and mortality in men with chronic HF and reduced left ventricular ejection fraction (LVEF). Design, Setting, and Participants: A prospective observational study at 2 tertiary cardiology centers (Wroclaw and Zabrze, Poland) of 501 men (mean [SD] age, 58 [12] years) with chronic HF, LVEF of 28% (SD, 8%), and New York Heart Association [NYHA] classes 1, 2, 3, and 4 of 52, 231, 181, and 37, respectively, who were recruited between January 1, 2002, and May 31, 2006. Cohort was divided into quintiles of serum estradiol (quintile 1,

Original languageEnglish
Pages (from-to)1892-1901
Number of pages10
JournalJournal of the American Medical Association
Volume301
Issue number18
DOIs
Publication statusPublished - May 13 2009

ASJC Scopus subject areas

  • Medicine(all)

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