TY - JOUR
T1 - Circulating estradiol, but not testosterone, is a significant predictor of high-grade prostate cancer in patients undergoing radical prostatectomy
AU - Salonia, Andrea
AU - Gallina, Andrea
AU - Briganti, Alberto
AU - Suardi, Nazareno
AU - Capitanio, Umberto
AU - Abdollah, Firas
AU - Bertini, Roberto
AU - Freschi, Massimo
AU - Rigatti, Patrizio
AU - Montorsi, Francesco
PY - 2011/11/15
Y1 - 2011/11/15
N2 - BACKGROUND: The objective of this study was to assess the association between preoperative circulating levels of 17β-estradiol (E
2) and high-grade prostate cancer (HGPCa) (Gleason grade ≥;4 + 3) at the time patients underwent radical retropubic prostatectomy (RRP). METHODS: Serum total testosterone (tT), sex hormone-binding globulin (SHBG), and E
2 levels were measured the day before surgery (8-10 AM) in a cohort of 655 consecutive Caucasian- European patients who underwent RRP at a single institution. Logistic regression models were used to test the association between predictors (including age, body mass index, prostate-specific antigen [PSA], clinical tumor classification, biopsy Gleason sum, tT, SHBG, and E
2) and HGPCa. Serum E
2 was included in the model as both a continuous variable and a categorized variable (according to the most informative cutoff: 50 pg/mL). RESULTS: Pathologic HGPCa was identified in 156 patients (23.8%). Patients with HGPCa had significantly higher PSA, clinical tumor classification, and biopsy Gleason sum than those without HGPCa (all P 2 was not associated significantly with HGPCa (odds ratio [OR], 1.009; P =.25), whereas patients with E
2 levels ≥50 pg/mL had a 3.24-fold increased risk of HGPCa (P 2 was associated significantly with HGPCa both as a continuous predictor (OR, 1.02; P =.04) and as a categorical predictor (OR, 3.94; P 2 was associated significantly with pathologic HGPCa, whereas SHBG and tT failed to demonstrate any association with HGPCa in patients who underwent RRP. Cancer
AB - BACKGROUND: The objective of this study was to assess the association between preoperative circulating levels of 17β-estradiol (E
2) and high-grade prostate cancer (HGPCa) (Gleason grade ≥;4 + 3) at the time patients underwent radical retropubic prostatectomy (RRP). METHODS: Serum total testosterone (tT), sex hormone-binding globulin (SHBG), and E
2 levels were measured the day before surgery (8-10 AM) in a cohort of 655 consecutive Caucasian- European patients who underwent RRP at a single institution. Logistic regression models were used to test the association between predictors (including age, body mass index, prostate-specific antigen [PSA], clinical tumor classification, biopsy Gleason sum, tT, SHBG, and E
2) and HGPCa. Serum E
2 was included in the model as both a continuous variable and a categorized variable (according to the most informative cutoff: 50 pg/mL). RESULTS: Pathologic HGPCa was identified in 156 patients (23.8%). Patients with HGPCa had significantly higher PSA, clinical tumor classification, and biopsy Gleason sum than those without HGPCa (all P 2 was not associated significantly with HGPCa (odds ratio [OR], 1.009; P =.25), whereas patients with E
2 levels ≥50 pg/mL had a 3.24-fold increased risk of HGPCa (P 2 was associated significantly with HGPCa both as a continuous predictor (OR, 1.02; P =.04) and as a categorical predictor (OR, 3.94; P 2 was associated significantly with pathologic HGPCa, whereas SHBG and tT failed to demonstrate any association with HGPCa in patients who underwent RRP. Cancer
KW - 17β
KW - estradiol
KW - high-grade prostate cancer
KW - prostate cancer
KW - radical prostatectomy
KW - testosterone
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U2 - 10.1002/cncr.26136
DO - 10.1002/cncr.26136
M3 - Article
C2 - 21495024
AN - SCOPUS:80054756183
VL - 117
SP - 5029
EP - 5038
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 22
ER -