Circulating free xeno-microRNAs - The new kids on the block

Linda Fabris, George Adrian Calin

Research output: Contribution to journalArticlepeer-review

Abstract

The role of circulating free microRNAs (cfmiRNAs) as promising tools for cancer screening, prognosis and monitoring of anticancer therapies has been widely studied in the past decades. cfmiRNAs have all the characteristics of the perfect biomarkers owing high stability under storage and handling conditions and being detectable not only in plasma, but in almost all body fluids. Moreover, their levels in plasma are likely to resemble ones in the primary tumor. Recently, viral and plant miRNAs have been found in plasma of healthy individuals through deep sequencing technique, and subsequently the same ones were deregulated in patients. Growing body of literature is recently focusing on understanding the potential cross-kingdom regulation of human mRNAs by miRNAs most likely absorbed with food ingestion. In this article we will review the literature concerning the xenomiRs detected in plasma and their role in influencing cancer onset and progression. XenomiRs could potentially be used not only as early screening tool, but also for patients' prognosis.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalMolecular Oncology
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Cancer
  • Circulating free microRNAs
  • microRNA
  • XenomiR

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Medicine

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