TY - JOUR
T1 - Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B - Relation to virus replication activity and liver cell necrosis
AU - Meliconi, Riccardo
AU - Baraldini, Mario
AU - Alberti, Alfredo
AU - Bortolotti, Flavia
AU - Realdi, Giuseppe
AU - Vacchini, Andrea
AU - Gasbarrini, Giovanni
AU - Labo, Giuseppe
PY - 1984/7
Y1 - 1984/7
N2 - Sera from two groups of untreated HBsAg-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to liver cell membrane antigens (liver-specific protein, LSP; and liver membrane antigen, LM-Ag). Among the 14 HBeAg-positive cases, seven (50%) were positive for anti-LSP, whereas only two (13%) of 15 anti-HBe-positive cases circulated this antibody. Liver membrane autoantibody (LMA) was detected only in two sera from delta-positive patients (1 HBeAg positive and 1 anti-HBe positive). Anti-LSP-positive patients presented transaminase values significantly higher than those of the negative cases. Our data do not support the hypothesis that a liver-specific autoimmune mechanism plays a significant role in the immunopathogenesis of liver cell necrosis in anti-HBe-positive chronic active hepatitis type B. The relationship between hepatocyte necrosis and anti-LSP antibody response is confirmed.
AB - Sera from two groups of untreated HBsAg-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to liver cell membrane antigens (liver-specific protein, LSP; and liver membrane antigen, LM-Ag). Among the 14 HBeAg-positive cases, seven (50%) were positive for anti-LSP, whereas only two (13%) of 15 anti-HBe-positive cases circulated this antibody. Liver membrane autoantibody (LMA) was detected only in two sera from delta-positive patients (1 HBeAg positive and 1 anti-HBe positive). Anti-LSP-positive patients presented transaminase values significantly higher than those of the negative cases. Our data do not support the hypothesis that a liver-specific autoimmune mechanism plays a significant role in the immunopathogenesis of liver cell necrosis in anti-HBe-positive chronic active hepatitis type B. The relationship between hepatocyte necrosis and anti-LSP antibody response is confirmed.
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U2 - 10.1007/BF01347294
DO - 10.1007/BF01347294
M3 - Article
C2 - 6734368
AN - SCOPUS:0021252803
VL - 29
SP - 620
EP - 624
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 7
ER -