Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B - Relation to virus replication activity and liver cell necrosis

Riccardo Meliconi; Mario Baraldini; Alfredo Alberti; Flavia Bortolotti; Giuseppe Realdi; Andrea Vacchini; Giovanni Gasbarrini; Giuseppe Labo

doi:10.1007/BF01347294

Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B - Relation to virus replication activity and liver cell necrosis

Riccardo Meliconi, Mario Baraldini, Alfredo Alberti, Flavia Bortolotti, Giuseppe Realdi, Andrea Vacchini, Giovanni Gasbarrini, Giuseppe Labo

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Sera from two groups of untreated HB_sAg-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to liver cell membrane antigens (liver-specific protein, LSP; and liver membrane antigen, LM-Ag). Among the 14 HB_eAg-positive cases, seven (50%) were positive for anti-LSP, whereas only two (13%) of 15 anti-HB_e-positive cases circulated this antibody. Liver membrane autoantibody (LMA) was detected only in two sera from delta-positive patients (1 HB_eAg positive and 1 anti-HB_e positive). Anti-LSP-positive patients presented transaminase values significantly higher than those of the negative cases. Our data do not support the hypothesis that a liver-specific autoimmune mechanism plays a significant role in the immunopathogenesis of liver cell necrosis in anti-HB_e-positive chronic active hepatitis type B. The relationship between hepatocyte necrosis and anti-LSP antibody response is confirmed.

Original language	English
Pages (from-to)	620-624
Number of pages	5
Journal	Digestive Diseases and Sciences
Volume	29
Issue number	7
DOIs	https://doi.org/10.1007/BF01347294
Publication status	Published - Jul 1984

ASJC Scopus subject areas

Gastroenterology

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10.1007/BF01347294

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Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B - Relation to virus replication activity and liver cell necrosis. / Meliconi, Riccardo; Baraldini, Mario; Alberti, Alfredo; Bortolotti, Flavia; Realdi, Giuseppe; Vacchini, Andrea; Gasbarrini, Giovanni; Labo, Giuseppe.

In: Digestive Diseases and Sciences, Vol. 29, No. 7, 07.1984, p. 620-624.

Research output: Contribution to journal › Article › peer-review

Meliconi, Riccardo ; Baraldini, Mario ; Alberti, Alfredo ; Bortolotti, Flavia ; Realdi, Giuseppe ; Vacchini, Andrea ; Gasbarrini, Giovanni ; Labo, Giuseppe. / Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B - Relation to virus replication activity and liver cell necrosis. In: Digestive Diseases and Sciences. 1984 ; Vol. 29, No. 7. pp. 620-624.

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title = "Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B - Relation to virus replication activity and liver cell necrosis",

abstract = "Sera from two groups of untreated HBsAg-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to liver cell membrane antigens (liver-specific protein, LSP; and liver membrane antigen, LM-Ag). Among the 14 HBeAg-positive cases, seven (50%) were positive for anti-LSP, whereas only two (13%) of 15 anti-HBe-positive cases circulated this antibody. Liver membrane autoantibody (LMA) was detected only in two sera from delta-positive patients (1 HBeAg positive and 1 anti-HBe positive). Anti-LSP-positive patients presented transaminase values significantly higher than those of the negative cases. Our data do not support the hypothesis that a liver-specific autoimmune mechanism plays a significant role in the immunopathogenesis of liver cell necrosis in anti-HBe-positive chronic active hepatitis type B. The relationship between hepatocyte necrosis and anti-LSP antibody response is confirmed.",

author = "Riccardo Meliconi and Mario Baraldini and Alfredo Alberti and Flavia Bortolotti and Giuseppe Realdi and Andrea Vacchini and Giovanni Gasbarrini and Giuseppe Labo",

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AU - Meliconi, Riccardo

AU - Baraldini, Mario

AU - Alberti, Alfredo

AU - Bortolotti, Flavia

AU - Realdi, Giuseppe

AU - Vacchini, Andrea

AU - Gasbarrini, Giovanni

AU - Labo, Giuseppe

PY - 1984/7

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N2 - Sera from two groups of untreated HBsAg-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to liver cell membrane antigens (liver-specific protein, LSP; and liver membrane antigen, LM-Ag). Among the 14 HBeAg-positive cases, seven (50%) were positive for anti-LSP, whereas only two (13%) of 15 anti-HBe-positive cases circulated this antibody. Liver membrane autoantibody (LMA) was detected only in two sera from delta-positive patients (1 HBeAg positive and 1 anti-HBe positive). Anti-LSP-positive patients presented transaminase values significantly higher than those of the negative cases. Our data do not support the hypothesis that a liver-specific autoimmune mechanism plays a significant role in the immunopathogenesis of liver cell necrosis in anti-HBe-positive chronic active hepatitis type B. The relationship between hepatocyte necrosis and anti-LSP antibody response is confirmed.

AB - Sera from two groups of untreated HBsAg-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to liver cell membrane antigens (liver-specific protein, LSP; and liver membrane antigen, LM-Ag). Among the 14 HBeAg-positive cases, seven (50%) were positive for anti-LSP, whereas only two (13%) of 15 anti-HBe-positive cases circulated this antibody. Liver membrane autoantibody (LMA) was detected only in two sera from delta-positive patients (1 HBeAg positive and 1 anti-HBe positive). Anti-LSP-positive patients presented transaminase values significantly higher than those of the negative cases. Our data do not support the hypothesis that a liver-specific autoimmune mechanism plays a significant role in the immunopathogenesis of liver cell necrosis in anti-HBe-positive chronic active hepatitis type B. The relationship between hepatocyte necrosis and anti-LSP antibody response is confirmed.

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