Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis. Characterization and correlation with the clinical course

S. Procaccia, D. Lanzanova, D. Caputo, P. Ferrante, E. Papini, A. Gasparini, A. Colucci, M. Bianchi, P. Villa, R. Blasio, M. Froldi, C. Zanussi

Research output: Contribution to journalArticlepeer-review

Abstract

We studied circulating immune complexes (IC) in the serum and cerebrospinal fluid (CSF) of patients with clinically defined multiple sclerosis (MS), in order to establish a correlation with the clinical course of the disease and to investigate the molecular composition of the IC isolated from patients in active phase of the disease. Serum IC levels were found to be significantly increased in patients from the progressive and active relapsing-remittent subgroups with both the CIC-conglutinin and C1q-binding methods. High levels of IC in CSF were detected only in the subgroup consisting of the relapsing-remittent patients in disease exacerbation when IC were determined by the C1q-binding test. No significant increase in serum or in CSF were found using the mRF-I test. The preliminary results of a qualitative investigation on serum IC in MS indicated that they are heterogenous in nature, their size is mainly of the intermediate type, and they contain IgG, IgM, complement components and β2-microglobulins, the latter presenting an observation both new and interesting for studies on serum IC in MS patients.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalActa Neurologica Scandinavica
Volume77
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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