Circulating inflammatory mediators as potential prognostic markers of human colorectal cancer

Giuseppe Di Caro, Michele Carvello, Samantha Angela Pesce, Marco Erreni, Federica Marchesi, Jelena Todoric, Matteo Sacchi, Marco Montorsi, Paola Allavena, Antonino Spinelli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background Cytokines and chemokines in the tumor microenvironment drive metastatic development and their serum levels might mirror the ongoing inflammatory reaction at the tumor site. Novel highly sensitive tools are needed to identify colorectal cancer patients at high risk of recurrence that should be more closelymonitored during post-surgical follow up. Here we study whether circulating inflammatorymarkers might be used to predict recurrence in CRC patients. Methods Circulating levels of the inflammatory cytokines IL-1, IL-6, IL-10, TNFalpha, CCL2, CXCL8, VEGF and the acute phase protein Pentraxin-3 were measured by ELISA in preoperative serum samples prospectively collected from a cohort of sixty-nine patients undergoing surgical resection for stage 0-IV CRC and associated with post-operative disease recurrence. Results Cox multivariate analysis showed that combined high levels (≥ROC cut off-value) of CXCL8, VEGF and Pentraxin3 were associated with increased risk of disease recurrence [HR: 14.28; 95%CI: (3.13-65.1)] independently of TNM staging. Kaplan-Meier analysis showed that CXCL8, VEGF and Pentraxin3 levels were significantly associated with worse survival (P

Original languageEnglish
Article numbere0148186
JournalPLoS One
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

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colorectal neoplasms
Vascular Endothelial Growth Factor A
Colorectal Neoplasms
relapse
Recurrence
Tumors
cytokines
Cytokines
neoplasms
acute phase proteins
Acute-Phase Proteins
interleukin-1
resection
chemokines
interleukin-10
Interleukin-1
Chemokines
interleukin-6
Interleukin-10
multivariate analysis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Circulating inflammatory mediators as potential prognostic markers of human colorectal cancer. / Di Caro, Giuseppe; Carvello, Michele; Pesce, Samantha Angela; Erreni, Marco; Marchesi, Federica; Todoric, Jelena; Sacchi, Matteo; Montorsi, Marco; Allavena, Paola; Spinelli, Antonino.

In: PLoS One, Vol. 11, No. 2, e0148186, 01.02.2016.

Research output: Contribution to journalArticle

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AU - Di Caro, Giuseppe

AU - Carvello, Michele

AU - Pesce, Samantha Angela

AU - Erreni, Marco

AU - Marchesi, Federica

AU - Todoric, Jelena

AU - Sacchi, Matteo

AU - Montorsi, Marco

AU - Allavena, Paola

AU - Spinelli, Antonino

PY - 2016/2/1

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N2 - Background Cytokines and chemokines in the tumor microenvironment drive metastatic development and their serum levels might mirror the ongoing inflammatory reaction at the tumor site. Novel highly sensitive tools are needed to identify colorectal cancer patients at high risk of recurrence that should be more closelymonitored during post-surgical follow up. Here we study whether circulating inflammatorymarkers might be used to predict recurrence in CRC patients. Methods Circulating levels of the inflammatory cytokines IL-1, IL-6, IL-10, TNFalpha, CCL2, CXCL8, VEGF and the acute phase protein Pentraxin-3 were measured by ELISA in preoperative serum samples prospectively collected from a cohort of sixty-nine patients undergoing surgical resection for stage 0-IV CRC and associated with post-operative disease recurrence. Results Cox multivariate analysis showed that combined high levels (≥ROC cut off-value) of CXCL8, VEGF and Pentraxin3 were associated with increased risk of disease recurrence [HR: 14.28; 95%CI: (3.13-65.1)] independently of TNM staging. Kaplan-Meier analysis showed that CXCL8, VEGF and Pentraxin3 levels were significantly associated with worse survival (P

AB - Background Cytokines and chemokines in the tumor microenvironment drive metastatic development and their serum levels might mirror the ongoing inflammatory reaction at the tumor site. Novel highly sensitive tools are needed to identify colorectal cancer patients at high risk of recurrence that should be more closelymonitored during post-surgical follow up. Here we study whether circulating inflammatorymarkers might be used to predict recurrence in CRC patients. Methods Circulating levels of the inflammatory cytokines IL-1, IL-6, IL-10, TNFalpha, CCL2, CXCL8, VEGF and the acute phase protein Pentraxin-3 were measured by ELISA in preoperative serum samples prospectively collected from a cohort of sixty-nine patients undergoing surgical resection for stage 0-IV CRC and associated with post-operative disease recurrence. Results Cox multivariate analysis showed that combined high levels (≥ROC cut off-value) of CXCL8, VEGF and Pentraxin3 were associated with increased risk of disease recurrence [HR: 14.28; 95%CI: (3.13-65.1)] independently of TNM staging. Kaplan-Meier analysis showed that CXCL8, VEGF and Pentraxin3 levels were significantly associated with worse survival (P

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