Circulating intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and plasma thrombomodulin levels in glioblastoma patients

A. Salmaggi, M. Eoli, S. Frigerio, E. Ciusani, A. Silvani, A. Boiardi

Research output: Contribution to journalArticlepeer-review

Abstract

Cellular adhesion molecules have been implicated in tumor progression and metastasis. Serum samples from 22 patients with glioblastoma (GBM), before surgery, and 19 sex and age matched healthy controls were analyzed for circulating levels of ICAM-1 and VCAM-1. At the same time also soluble plasma thrombomodulin, a marker of endothelial cell damage and activation, was detected. Soluble ICAM-1 and VCAM-1 levels were comparable in glioblastoma patients and healthy controls, while plasma thrombomodulin (TM) was significantly increased in cancer patients. There was no correlation between thrombomodulin levels and the presence of an intratumoral hemorrhage detected by CT scan, while entity of post-contrast enhacemement at CT correlated with higher TM levels. Further study with serial sampling of GBM patients and correlation with enhancement at CT will allow to ascertain the value of serum TM as a marker of disease recurrence or angiogenesis in those tumors. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalCancer Letters
Volume146
Issue number2
DOIs
Publication statusPublished - Nov 15 1999

Keywords

  • Adhesion molecules: Thrombomodulin
  • Glioblastoma

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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