Circulating levels of cytokines and their site of production in patients with mild to severe chronic heart failure.

M. Petretta, G. L. Condorelli, L. Spinelli, F. Scopacasa, M. de Caterina, D. Leosco, M. L. Vicario, D. Bonaduce

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Patients with chronic heart failure have elevated levels of proinflammatory cytokines; however, the mechanism for their increased expression and the site of their production are unknown. METHODS: Twenty-two patients with heart failure, New York Heart Association functional class II to IV, underwent hemodynamic evaluation and echocardiographic study. Blood samples for cytokine evaluation were performed in the ascending aorta, coronary sinus, inferior vena cava, and hepatic vein. Levels of tumor necrosis factor-alpha (TNF-alpha), its soluble receptors sTNF-RI and sTNF-RII, interleukin-6 (IL-6), IL-6 soluble receptor, soluble gp130, interleukin-2 soluble receptor, and soluble Fas were measured with enzyme-linked immunosorbent assay kits. RESULTS: IL-6 concentrations were higher in class IV patients than in class III patients, which in turn were higher than those in class II. TNF-alpha, sTNF-RI, and sTNF-RII were higher in class IV patients than in class III and II patients. Significant correlations were found between IL-6 concentrations and left ventricular end-systolic volume (r = 0.64; P

Original languageEnglish
JournalAmerican Heart Journal
Volume140
Issue number6
DOIs
Publication statusPublished - Dec 2000

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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