Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women

E. Romagnoli, S. Minisola, V. Carnevale, R. Rosso, M. T. Pacitti, A. Scarda, L. Scarnecchia, G. Mazzuoli

Research output: Contribution to journalArticlepeer-review

Abstract

The study investigated possible menopause-related changes in circulating insulin-like growth factor binding protein 3 (IGFBP-3) levels and their relationship with insulin-like growth factor I (IGF-I) plasma levels. Forty-three healthy women, aged 45-55 years, were studied (22 premenopausal and 21 postmeno-pausal, matched for age and body mass index); in all subjects plasma IGF-I and IGFBP-3 levels were measured by radioimmunoassay. No difference was found between mean IGFBP-3 plasma levels in the two groups studied (premenopausal 3.42±0.49 v postmenopausal 3.46±0.58 mg/l), while mean IGF-I levels were significantly lower in postmenopausal as compared with premenopausal women (136.7±37.86 v 175.7±51.91 ng/ml, p

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalOsteoporosis International
Volume4
Issue number6
DOIs
Publication statusPublished - Nov 1994

Keywords

  • Insulin-like growth factor binding protein 3
  • Menopause

ASJC Scopus subject areas

  • Medicine(all)

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