Circulating levels of interleukin-17A and interleukin-23 are increased in patients with gonococcal infection

Maria Cristina Gagliardi, Stefania Starnino, Raffaela Teloni, Sabrina Mariotti, Ivano Dal Conte, Aldo Di Carlo, Paola Stefanelli

Research output: Contribution to journalArticle

Abstract

Neisseria gonorrhoeae is the etiological agent of gonorrhoea, an infectious disease characterized by acute inflammation of the urogenital tract with a massive infiltration of neutrophils. Polymorphonuclear leukocyte recruitment is one of the activities of the recently described interleukin-17A (IL-17A); thus, we analyzed the serum concentration of IL-17A, together with IL-23 and interferon-γ (IFN-γ), in 27 patients with gonorrhoea. The concentration of these cytokines in patients' sera was significantly higher than that detected in healthy controls and an inverse correlation was found between the concentrations of IL-17A and IFN-γ. This is the first report showing a significant increase of IL-17A and IL-23 serum levels in patients with gonorrhoea, suggesting new players in the immune response to N. gonorrhoeae. FEMS Immunology & Medical Microbiology

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalFEMS Immunology and Medical Microbiology
Volume61
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Gonorrhoea
  • Interleukin-17A
  • Interleukin-23

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

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    Gagliardi, M. C., Starnino, S., Teloni, R., Mariotti, S., Dal Conte, I., Di Carlo, A., & Stefanelli, P. (2011). Circulating levels of interleukin-17A and interleukin-23 are increased in patients with gonococcal infection. FEMS Immunology and Medical Microbiology, 61(1), 129-132. https://doi.org/10.1111/j.1574-695X.2010.00759.x