Circulating levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in children with autoimmune hepatitis

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Abstract

Circulating levels of the proinflammatory cytokines interleukin-6 (IL-6), IL-8, and tumor necrosis factor-α (TNF-α) were measured in 13 children with autoimmune hepatitis (AIH) (seven with type 1 and six with type 2). In untreated children with type 1 AIH, TNF-α, IL-6, and IL-8 levels were elevated when compared to those of healthy controls (p <0.005, p <0.02, p = 0.06, respectively), whereas in children with type 2 AIH, cytokine levels were normal in all except one sample. A significant decrease in circulating IL-6, IL-8, and TNF-α was observed when patients were evaluated during a subsequent remission. We found no significant correlation of cytokine levels with alanine aminotransferase (ALT) activity, total serum γ-globulins, or prothrombin activity. In patients with cirrhosis, serum IL-8 and IL-6 levels were higher (significantly in the case of IL-8) than those of patients without cirrhosis. In conclusion, activation of the in vivo production of the proinflammatory cytokines IL-6, IL-8, and TNF-α appears to be associated with type 1 but not with type 2 AIH.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume20
Issue number1
Publication statusPublished - 1995

Keywords

  • Autoimmune hepatitis
  • Child
  • Cytokines
  • Interleukin-6
  • Interleukin-8
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Medicine (miscellaneous)
  • Histology

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