Circulating levels of soluble E-selectin, P-selectin and intercellular adhesion molecule-1 in patients with juvenile idiopathic arthritis

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Abstract

Objective. To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels. Methods. Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls. Results. Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin, sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1β. Conclusion. Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA, suggests that TNF activated endothelial cells are the soure of sE-selectin and sICAM-1 in this disease.

Original languageEnglish
Pages (from-to)2246-2250
Number of pages5
JournalJournal of Rheumatology
Volume27
Issue number9
Publication statusPublished - 2000

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P-Selectin
E-Selectin
Juvenile Arthritis
Intercellular Adhesion Molecule-1
Selectins
Receptors, Tumor Necrosis Factor, Type II
Serum
Interleukin-1
Interleukin-6
Endothelial Cells
Enzyme-Linked Immunosorbent Assay
Cytokines

Keywords

  • E-selectin
  • Intercellular adhesion molecule-1
  • Juvenile rheumatoid arthritis
  • Tumor necrosis factor
  • Tumor necrosis factor receptor

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

@article{7eb931fa380f4db3b206dbad4f37fced,
title = "Circulating levels of soluble E-selectin, P-selectin and intercellular adhesion molecule-1 in patients with juvenile idiopathic arthritis",
abstract = "Objective. To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels. Methods. Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls. Results. Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin, sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1β. Conclusion. Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA, suggests that TNF activated endothelial cells are the soure of sE-selectin and sICAM-1 in this disease.",
keywords = "E-selectin, Intercellular adhesion molecule-1, Juvenile rheumatoid arthritis, Tumor necrosis factor, Tumor necrosis factor receptor",
author = "{De Benedetti}, F. and M. Vivarelli and P. Pignatti and M. Oliveri and M. Massa and A. Pistorio and A. Martini",
year = "2000",
language = "English",
volume = "27",
pages = "2246--2250",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "9",

}

TY - JOUR

T1 - Circulating levels of soluble E-selectin, P-selectin and intercellular adhesion molecule-1 in patients with juvenile idiopathic arthritis

AU - De Benedetti, F.

AU - Vivarelli, M.

AU - Pignatti, P.

AU - Oliveri, M.

AU - Massa, M.

AU - Pistorio, A.

AU - Martini, A.

PY - 2000

Y1 - 2000

N2 - Objective. To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels. Methods. Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls. Results. Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin, sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1β. Conclusion. Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA, suggests that TNF activated endothelial cells are the soure of sE-selectin and sICAM-1 in this disease.

AB - Objective. To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels. Methods. Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls. Results. Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin, sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1β. Conclusion. Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA, suggests that TNF activated endothelial cells are the soure of sE-selectin and sICAM-1 in this disease.

KW - E-selectin

KW - Intercellular adhesion molecule-1

KW - Juvenile rheumatoid arthritis

KW - Tumor necrosis factor

KW - Tumor necrosis factor receptor

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M3 - Article

C2 - 10990242

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VL - 27

SP - 2246

EP - 2250

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 9

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