Abstract
Objective. To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels. Methods. Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls. Results. Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin, sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1β. Conclusion. Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA, suggests that TNF activated endothelial cells are the soure of sE-selectin and sICAM-1 in this disease.
| Original language | English |
|---|---|
| Pages (from-to) | 2246-2250 |
| Number of pages | 5 |
| Journal | Journal of Rheumatology |
| Volume | 27 |
| Issue number | 9 |
| Publication status | Published - 2000 |
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Keywords
- E-selectin
- Intercellular adhesion molecule-1
- Juvenile rheumatoid arthritis
- Tumor necrosis factor
- Tumor necrosis factor receptor
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Circulating levels of soluble E-selectin, P-selectin and intercellular adhesion molecule-1 in patients with juvenile idiopathic arthritis. / De Benedetti, F.; Vivarelli, M.; Pignatti, P.; Oliveri, M.; Massa, M.; Pistorio, A.; Martini, A.
In: Journal of Rheumatology, Vol. 27, No. 9, 2000, p. 2246-2250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Circulating levels of soluble E-selectin, P-selectin and intercellular adhesion molecule-1 in patients with juvenile idiopathic arthritis
AU - De Benedetti, F.
AU - Vivarelli, M.
AU - Pignatti, P.
AU - Oliveri, M.
AU - Massa, M.
AU - Pistorio, A.
AU - Martini, A.
PY - 2000
Y1 - 2000
N2 - Objective. To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels. Methods. Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls. Results. Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin, sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1β. Conclusion. Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA, suggests that TNF activated endothelial cells are the soure of sE-selectin and sICAM-1 in this disease.
AB - Objective. To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels. Methods. Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls. Results. Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin, sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1β. Conclusion. Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA, suggests that TNF activated endothelial cells are the soure of sE-selectin and sICAM-1 in this disease.
KW - E-selectin
KW - Intercellular adhesion molecule-1
KW - Juvenile rheumatoid arthritis
KW - Tumor necrosis factor
KW - Tumor necrosis factor receptor
UR - http://www.scopus.com/inward/record.url?scp=0033821914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033821914&partnerID=8YFLogxK
M3 - Article
C2 - 10990242
AN - SCOPUS:0033821914
VL - 27
SP - 2246
EP - 2250
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 9
ER -