Circulating microRNAs and bioinformatics tools to discover novel diagnostic biomarkers of pediatric diseases

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Current studies have shown that miRNAs are also present in extracellular spaces, packaged into various membrane-bound vesicles, or associated with RNA-binding proteins. Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. In fact, their remarkable stability and the relative ease of detection make circulating miRNAs ideal tools for rapid and non-invasive diagnosis. This review summarizes recent insights about the origin, functions and diagnostic potential of extracellular miRNAs by especially focusing on pediatric diseases in order to explore the feasibility of alternative sampling sources for the development of non-invasive pediatric diagnostics. We will also discuss specific bioinformatics tools and databases for circulating miRNAs focused on the identification and discovery of novel diagnostic biomarkers of pediatric diseases.

Original languageEnglish
Article number234
JournalGenes
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 19 2017

Fingerprint

Computational Biology
MicroRNAs
Biomarkers
Pediatrics
Physiological Phenomena
Small Untranslated RNA
RNA-Binding Proteins
Extracellular Space
Body Fluids
Databases
Gene Expression
Membranes

Keywords

  • Bioinformatics tools
  • Biomarkers
  • Body fluids
  • Circulating microRNAs
  • Pediatric diseases

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Circulating microRNAs and bioinformatics tools to discover novel diagnostic biomarkers of pediatric diseases. / Baldassarre, Antonella; Felli, Cristina; Prantera, Giorgio; Masotti, Andrea.

In: Genes, Vol. 8, No. 9, 234, 19.09.2017.

Research output: Contribution to journalReview article

@article{76fd50a173084f72826063a7d704a6a9,
title = "Circulating microRNAs and bioinformatics tools to discover novel diagnostic biomarkers of pediatric diseases",
abstract = "MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Current studies have shown that miRNAs are also present in extracellular spaces, packaged into various membrane-bound vesicles, or associated with RNA-binding proteins. Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. In fact, their remarkable stability and the relative ease of detection make circulating miRNAs ideal tools for rapid and non-invasive diagnosis. This review summarizes recent insights about the origin, functions and diagnostic potential of extracellular miRNAs by especially focusing on pediatric diseases in order to explore the feasibility of alternative sampling sources for the development of non-invasive pediatric diagnostics. We will also discuss specific bioinformatics tools and databases for circulating miRNAs focused on the identification and discovery of novel diagnostic biomarkers of pediatric diseases.",
keywords = "Bioinformatics tools, Biomarkers, Body fluids, Circulating microRNAs, Pediatric diseases",
author = "Antonella Baldassarre and Cristina Felli and Giorgio Prantera and Andrea Masotti",
year = "2017",
month = "9",
day = "19",
doi = "10.3390/genes8090234",
language = "English",
volume = "8",
journal = "Genes",
issn = "2073-4425",
publisher = "MDPI AG",
number = "9",

}

TY - JOUR

T1 - Circulating microRNAs and bioinformatics tools to discover novel diagnostic biomarkers of pediatric diseases

AU - Baldassarre, Antonella

AU - Felli, Cristina

AU - Prantera, Giorgio

AU - Masotti, Andrea

PY - 2017/9/19

Y1 - 2017/9/19

N2 - MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Current studies have shown that miRNAs are also present in extracellular spaces, packaged into various membrane-bound vesicles, or associated with RNA-binding proteins. Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. In fact, their remarkable stability and the relative ease of detection make circulating miRNAs ideal tools for rapid and non-invasive diagnosis. This review summarizes recent insights about the origin, functions and diagnostic potential of extracellular miRNAs by especially focusing on pediatric diseases in order to explore the feasibility of alternative sampling sources for the development of non-invasive pediatric diagnostics. We will also discuss specific bioinformatics tools and databases for circulating miRNAs focused on the identification and discovery of novel diagnostic biomarkers of pediatric diseases.

AB - MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Current studies have shown that miRNAs are also present in extracellular spaces, packaged into various membrane-bound vesicles, or associated with RNA-binding proteins. Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. In fact, their remarkable stability and the relative ease of detection make circulating miRNAs ideal tools for rapid and non-invasive diagnosis. This review summarizes recent insights about the origin, functions and diagnostic potential of extracellular miRNAs by especially focusing on pediatric diseases in order to explore the feasibility of alternative sampling sources for the development of non-invasive pediatric diagnostics. We will also discuss specific bioinformatics tools and databases for circulating miRNAs focused on the identification and discovery of novel diagnostic biomarkers of pediatric diseases.

KW - Bioinformatics tools

KW - Biomarkers

KW - Body fluids

KW - Circulating microRNAs

KW - Pediatric diseases

UR - http://www.scopus.com/inward/record.url?scp=85029147491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029147491&partnerID=8YFLogxK

U2 - 10.3390/genes8090234

DO - 10.3390/genes8090234

M3 - Review article

AN - SCOPUS:85029147491

VL - 8

JO - Genes

JF - Genes

SN - 2073-4425

IS - 9

M1 - 234

ER -