Circulating miR-146a in healthy aging and type 2 diabetes: Age- and gender-specific trajectories

Emanuela Mensà, Angelica Giuliani, Giulia Matacchione, Felicia Gurău, Anna Rita Bonfigli, Fabio Romagnoli, Maria De Luca, Jacopo Sabbatinelli, Fabiola Olivieri

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR‐146a levels, 188 healthy subjects (CTR) aged 20–104 years and 144 type-2 diabetic patients (T2DM), aged 40‐80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran, the miR‐146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. In women, miR-146a circulating levels showed negative correlations with azotemia, uric acid, waist/hip ratio and ferritin. A significant miR-146a decline with aging was also observed in T2DM patients. Significant positive correlations were found between miR-146a in diabetic patients and total cholesterol, LDL-C, ApoA1, ApoB, and platelets, and negative correlations with serum iron and ferritin. Notably, miR-146a was significantly overexpressed in T2DM patients treated with metformin. MiR-146a levels were significantly lower in diabetic patients than in age-matched CTR and negatively correlated to both fasting glucose and HbA1c in males. Finally, age-related trajectories for circulating miR-146a levels showed an inverted U-shaped relationship; however, in T2DM patients the trajectory was significantly shifted towards lower levels. Our findings support the hypothesis that miR-146a could be a functional biomarker of healthy/unhealthy aging.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalMechanisms of Ageing and Development
Volume180
DOIs
Publication statusPublished - Jun 1 2019

Fingerprint

Type 2 Diabetes Mellitus
Ferritins
Uric Acid
Azotemia
Waist-Hip Ratio
Metformin
Plasminogen Activator Inhibitor 1
Apolipoproteins B
LDL Cholesterol
Fasting
Creatinine
Healthy Volunteers
Blood Platelets
Iron
Biomarkers
Glucose
Serum

Keywords

  • Age-associated diseases
  • Glycated hemoglobin
  • Inflammation
  • Lipid profile
  • microRNA

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

Cite this

Circulating miR-146a in healthy aging and type 2 diabetes : Age- and gender-specific trajectories. / Mensà, Emanuela; Giuliani, Angelica; Matacchione, Giulia; Gurău, Felicia; Bonfigli, Anna Rita; Romagnoli, Fabio; De Luca, Maria; Sabbatinelli, Jacopo; Olivieri, Fabiola.

In: Mechanisms of Ageing and Development, Vol. 180, 01.06.2019, p. 1-10.

Research output: Contribution to journalArticle

@article{e3d7f8e94580411b9de38d8cf99ef90d,
title = "Circulating miR-146a in healthy aging and type 2 diabetes: Age- and gender-specific trajectories",
abstract = "To evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR‐146a levels, 188 healthy subjects (CTR) aged 20–104 years and 144 type-2 diabetic patients (T2DM), aged 40‐80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran, the miR‐146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. In women, miR-146a circulating levels showed negative correlations with azotemia, uric acid, waist/hip ratio and ferritin. A significant miR-146a decline with aging was also observed in T2DM patients. Significant positive correlations were found between miR-146a in diabetic patients and total cholesterol, LDL-C, ApoA1, ApoB, and platelets, and negative correlations with serum iron and ferritin. Notably, miR-146a was significantly overexpressed in T2DM patients treated with metformin. MiR-146a levels were significantly lower in diabetic patients than in age-matched CTR and negatively correlated to both fasting glucose and HbA1c in males. Finally, age-related trajectories for circulating miR-146a levels showed an inverted U-shaped relationship; however, in T2DM patients the trajectory was significantly shifted towards lower levels. Our findings support the hypothesis that miR-146a could be a functional biomarker of healthy/unhealthy aging.",
keywords = "Age-associated diseases, Glycated hemoglobin, Inflammation, Lipid profile, microRNA",
author = "Emanuela Mens{\`a} and Angelica Giuliani and Giulia Matacchione and Felicia Gurău and Bonfigli, {Anna Rita} and Fabio Romagnoli and {De Luca}, Maria and Jacopo Sabbatinelli and Fabiola Olivieri",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.mad.2019.03.001",
language = "English",
volume = "180",
pages = "1--10",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Circulating miR-146a in healthy aging and type 2 diabetes

T2 - Age- and gender-specific trajectories

AU - Mensà, Emanuela

AU - Giuliani, Angelica

AU - Matacchione, Giulia

AU - Gurău, Felicia

AU - Bonfigli, Anna Rita

AU - Romagnoli, Fabio

AU - De Luca, Maria

AU - Sabbatinelli, Jacopo

AU - Olivieri, Fabiola

PY - 2019/6/1

Y1 - 2019/6/1

N2 - To evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR‐146a levels, 188 healthy subjects (CTR) aged 20–104 years and 144 type-2 diabetic patients (T2DM), aged 40‐80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran, the miR‐146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. In women, miR-146a circulating levels showed negative correlations with azotemia, uric acid, waist/hip ratio and ferritin. A significant miR-146a decline with aging was also observed in T2DM patients. Significant positive correlations were found between miR-146a in diabetic patients and total cholesterol, LDL-C, ApoA1, ApoB, and platelets, and negative correlations with serum iron and ferritin. Notably, miR-146a was significantly overexpressed in T2DM patients treated with metformin. MiR-146a levels were significantly lower in diabetic patients than in age-matched CTR and negatively correlated to both fasting glucose and HbA1c in males. Finally, age-related trajectories for circulating miR-146a levels showed an inverted U-shaped relationship; however, in T2DM patients the trajectory was significantly shifted towards lower levels. Our findings support the hypothesis that miR-146a could be a functional biomarker of healthy/unhealthy aging.

AB - To evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR‐146a levels, 188 healthy subjects (CTR) aged 20–104 years and 144 type-2 diabetic patients (T2DM), aged 40‐80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran, the miR‐146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. In women, miR-146a circulating levels showed negative correlations with azotemia, uric acid, waist/hip ratio and ferritin. A significant miR-146a decline with aging was also observed in T2DM patients. Significant positive correlations were found between miR-146a in diabetic patients and total cholesterol, LDL-C, ApoA1, ApoB, and platelets, and negative correlations with serum iron and ferritin. Notably, miR-146a was significantly overexpressed in T2DM patients treated with metformin. MiR-146a levels were significantly lower in diabetic patients than in age-matched CTR and negatively correlated to both fasting glucose and HbA1c in males. Finally, age-related trajectories for circulating miR-146a levels showed an inverted U-shaped relationship; however, in T2DM patients the trajectory was significantly shifted towards lower levels. Our findings support the hypothesis that miR-146a could be a functional biomarker of healthy/unhealthy aging.

KW - Age-associated diseases

KW - Glycated hemoglobin

KW - Inflammation

KW - Lipid profile

KW - microRNA

UR - http://www.scopus.com/inward/record.url?scp=85063028711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063028711&partnerID=8YFLogxK

U2 - 10.1016/j.mad.2019.03.001

DO - 10.1016/j.mad.2019.03.001

M3 - Article

C2 - 30880174

AN - SCOPUS:85063028711

VL - 180

SP - 1

EP - 10

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

ER -