Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

Anna Picca, Angela Maria Serena Lezza, Christiaan Leeuwenburgh, Vito Pesce, Riccardo Calvani, Maurizio Bossola, Ester Manes-Gravina, Francesco Landi, Roberto Bernabei, Emanuele Marzetti

Research output: Contribution to journalArticlepeer-review

Abstract

Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscle wasting disorders, including sarcopenia and cachexia. One of the consequences of failing MQC is the release of mitochondria-derived damage-associated molecular patterns (DAMPs). By virtue of their bacterial ancestry, these molecules can trigger an inflammatory response by interacting with receptors similar to those involved in pathogen-associated responses. Mitochondria-derived DAMPs, especially cell-free mitochondrial DNA, have recently been associated with conditions characterized by chronic inflammation, such as aging and degenerative diseases. Yet, their actual implication in the aging process and muscle wasting disorders is at an early stage of investigation. Here, we review the contribution of mitochondria-derived DAMPs to age-related systemic inflammation. We also provide arguments in support of the exploitation of such signaling pathways for the management of muscle wasting conditions.

Original languageEnglish
Pages (from-to)350-359
Number of pages10
JournalRejuvenation Research
Volume21
Issue number4
DOIs
Publication statusPublished - Aug 1 2018

Keywords

  • autophagy
  • cachexia
  • DAMPs
  • mitochondrial biogenesis
  • mitochondrial quality control
  • sarcopenia

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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