Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients

Giuseppe Roscilli; Manuela Cappelletti; Claudia De Vitis; Gennaro Ciliberto; Arianna Di Napoli; Luigi Ruco; Rita Mancini; Luigi Aurisicchio

doi:10.1186/1479-5876-12-54

Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients

Giuseppe Roscilli, Manuela Cappelletti, Claudia De Vitis, Gennaro Ciliberto, Arianna Di Napoli, Luigi Ruco, Rita Mancini, Luigi Aurisicchio

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Tumor Associated Antigens are characterized by spontaneous immune response in cancer patients as a consequence of overexpression and epitope-presentation on MHC class I/II machinery. Matrix Metalloprotease 11 (MMP11) expression has been associated with poor prognosis for several cancer types, including breast and prostate cancer.Methods: MMP11 expression was determined by immunoistochemistry in breast and prostate cancer samples. Circulating MMP11 protein as well as the spontaneous immune responses against MMP11 were analyzed in a set of breast and prostate cancer patients.Results: In plasma samples MMP11 protein was present in 5/13 breast cancer patients and in 1/12 prostate cancer patients. An antibody response was observed in 7/13 breast cancer patients and in 3/12 prostate cancer patients.Conclusions: These findings further suggest MMP11 as a promising biomarker for these tumor types and a suitable target for cancer immunotherapy strategies.

Original language	English
Article number	54
Journal	Journal of Translational Medicine
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1479-5876-12-54
Publication status	Published - Feb 24 2014

Keywords

Immune response
MMP11
Tumor stroma

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. / Roscilli, Giuseppe; Cappelletti, Manuela; De Vitis, Claudia; Ciliberto, Gennaro; Di Napoli, Arianna; Ruco, Luigi; Mancini, Rita; Aurisicchio, Luigi.

In: Journal of Translational Medicine, Vol. 12, No. 1, 54, 24.02.2014.

Research output: Contribution to journal › Article › peer-review

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AU - Ruco, Luigi

AU - Mancini, Rita

AU - Aurisicchio, Luigi

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