Circulating plasma surfactant protein type B as biological marker of alveolar-capillary barrier damage in chronic heart failure

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Abstract

Background-Surfactant protein type B (SPB) is needed for alveolar gas exchange. SPB is increased in the plasma of patients with heart failure (HF), with a concentration that is higher when HF severity is highest. The aim of this study was to evaluate the relationship between plasma SPB and both alveolar-capillary diffusion at rest and ventilation versus carbon dioxide production during exercise. Methods and Results-Eighty patients with chronic HF and 20 healthy controls were evaluated consecutively, but the required quality for procedures was only reached by 71 patients with HF and 19 healthy controls. Each subject underwent pulmonary function measurements, including lung diffusion for carbon monoxide and membrane diffusion capacity, and maximal cardiopulmonary exercise test. Plasma SPB was measured by immunoblotting. In patients with HF, SPB values were higher (4.5 [11.1] versus 1.6 [2.9], P=0.0006, median and 25th to 75th interquartile), whereas lung diffusion for carbon monoxide (19.7±4.5 versus 24.6±6.8 mL/mm Hg per min, P

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalCirculation: Heart Failure
Volume2
Issue number3
DOIs
Publication statusPublished - May 2009

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Surface-Active Agents
Blood Proteins
Heart Failure
Biomarkers
Carbon Monoxide
Lung
Exercise Test
Immunoblotting
Carbon Dioxide
Ventilation
Gases
IgA receptor
Exercise
Membranes

Keywords

  • Alveolar-capillary barrier damage
  • Cardiopulmonary exercise test
  • Chronic heart failure
  • Lung diffusion
  • Surfactant protein B

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Circulating plasma surfactant protein type B as biological marker of alveolar-capillary barrier damage in chronic heart failure",
abstract = "Background-Surfactant protein type B (SPB) is needed for alveolar gas exchange. SPB is increased in the plasma of patients with heart failure (HF), with a concentration that is higher when HF severity is highest. The aim of this study was to evaluate the relationship between plasma SPB and both alveolar-capillary diffusion at rest and ventilation versus carbon dioxide production during exercise. Methods and Results-Eighty patients with chronic HF and 20 healthy controls were evaluated consecutively, but the required quality for procedures was only reached by 71 patients with HF and 19 healthy controls. Each subject underwent pulmonary function measurements, including lung diffusion for carbon monoxide and membrane diffusion capacity, and maximal cardiopulmonary exercise test. Plasma SPB was measured by immunoblotting. In patients with HF, SPB values were higher (4.5 [11.1] versus 1.6 [2.9], P=0.0006, median and 25th to 75th interquartile), whereas lung diffusion for carbon monoxide (19.7±4.5 versus 24.6±6.8 mL/mm Hg per min, P",
keywords = "Alveolar-capillary barrier damage, Cardiopulmonary exercise test, Chronic heart failure, Lung diffusion, Surfactant protein B",
author = "Damiano Magr{\`i} and Maura Brioschi and Cristina Banfi and Schmid, {Jean Paul} and Pietro Palermo and Mauro Contini and Anna Apostolo and Maurizio Bussotti and Elena Tremoli and Susanna Sciomer and Gaia Cattadori and Cesare Fiorentini and Piergiuseppe Agostoni",
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AU - Magrì, Damiano

AU - Brioschi, Maura

AU - Banfi, Cristina

AU - Schmid, Jean Paul

AU - Palermo, Pietro

AU - Contini, Mauro

AU - Apostolo, Anna

AU - Bussotti, Maurizio

AU - Tremoli, Elena

AU - Sciomer, Susanna

AU - Cattadori, Gaia

AU - Fiorentini, Cesare

AU - Agostoni, Piergiuseppe

PY - 2009/5

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N2 - Background-Surfactant protein type B (SPB) is needed for alveolar gas exchange. SPB is increased in the plasma of patients with heart failure (HF), with a concentration that is higher when HF severity is highest. The aim of this study was to evaluate the relationship between plasma SPB and both alveolar-capillary diffusion at rest and ventilation versus carbon dioxide production during exercise. Methods and Results-Eighty patients with chronic HF and 20 healthy controls were evaluated consecutively, but the required quality for procedures was only reached by 71 patients with HF and 19 healthy controls. Each subject underwent pulmonary function measurements, including lung diffusion for carbon monoxide and membrane diffusion capacity, and maximal cardiopulmonary exercise test. Plasma SPB was measured by immunoblotting. In patients with HF, SPB values were higher (4.5 [11.1] versus 1.6 [2.9], P=0.0006, median and 25th to 75th interquartile), whereas lung diffusion for carbon monoxide (19.7±4.5 versus 24.6±6.8 mL/mm Hg per min, P

AB - Background-Surfactant protein type B (SPB) is needed for alveolar gas exchange. SPB is increased in the plasma of patients with heart failure (HF), with a concentration that is higher when HF severity is highest. The aim of this study was to evaluate the relationship between plasma SPB and both alveolar-capillary diffusion at rest and ventilation versus carbon dioxide production during exercise. Methods and Results-Eighty patients with chronic HF and 20 healthy controls were evaluated consecutively, but the required quality for procedures was only reached by 71 patients with HF and 19 healthy controls. Each subject underwent pulmonary function measurements, including lung diffusion for carbon monoxide and membrane diffusion capacity, and maximal cardiopulmonary exercise test. Plasma SPB was measured by immunoblotting. In patients with HF, SPB values were higher (4.5 [11.1] versus 1.6 [2.9], P=0.0006, median and 25th to 75th interquartile), whereas lung diffusion for carbon monoxide (19.7±4.5 versus 24.6±6.8 mL/mm Hg per min, P

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KW - Lung diffusion

KW - Surfactant protein B

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