Circulating plasma surfactant protein type B as biological marker of alveolar-capillary barrier damage in chronic heart failure

Research output: Contribution to journalArticle

Abstract

Background-Surfactant protein type B (SPB) is needed for alveolar gas exchange. SPB is increased in the plasma of patients with heart failure (HF), with a concentration that is higher when HF severity is highest. The aim of this study was to evaluate the relationship between plasma SPB and both alveolar-capillary diffusion at rest and ventilation versus carbon dioxide production during exercise. Methods and Results-Eighty patients with chronic HF and 20 healthy controls were evaluated consecutively, but the required quality for procedures was only reached by 71 patients with HF and 19 healthy controls. Each subject underwent pulmonary function measurements, including lung diffusion for carbon monoxide and membrane diffusion capacity, and maximal cardiopulmonary exercise test. Plasma SPB was measured by immunoblotting. In patients with HF, SPB values were higher (4.5 [11.1] versus 1.6 [2.9], P=0.0006, median and 25th to 75th interquartile), whereas lung diffusion for carbon monoxide (19.7±4.5 versus 24.6±6.8 mL/mm Hg per min, P

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalCirculation: Heart Failure
Volume2
Issue number3
DOIs
Publication statusPublished - May 2009

Keywords

  • Alveolar-capillary barrier damage
  • Cardiopulmonary exercise test
  • Chronic heart failure
  • Lung diffusion
  • Surfactant protein B

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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