Circulating platelet aggregates: a chronic platelet activation in patients with transient ischaemic attacks

M. De Marinis, C. Fieschi, M. Prencipe, R. Falchetti, S. Paolucci

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet hyperaggregability was tested in 62 TIA patients by means of the formalin fixing principle of Wu and Hoak. Compared to age-matched controls, the platelet aggregates ratio (PAR) was reduced from 0.99±0.04 SD to 0.807±0.14 SD. This means a highly significant increase of circulating platelet aggregates (CPA) in untreated TIA patients, regardless of the interval sinche the last attack (from 2 days to 1 year). PAR was especially reduced in patients with abnormal angiography (expressing pronounced cerebral or diffuse ATS) and it was possibly affected by previous antiplatelet treatment with ASA.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalItalian Journal of Neurological Sciences
Volume1
Issue number2
DOIs
Publication statusPublished - Jun 1979

Keywords

  • Antiplatelet Therapy
  • Chronic Platelet Activation
  • Circulating Platelet Aggregates
  • Tias

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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