Circulating PV-1 as a marker of celiac disease-associated liver injury

Luigina De Leo, Samuele Naviglio, Serena Vatta, Elisa Benelli, Giacomo Stera, Daniela Santon, Fabiana Ziberna, Andrea Taddio, Stefano Martelossi, Fabiola Giudici, Paolo Giuffrida, Antonio Di Sabatino, Gino R. Corazza, Alessandro Ventura, Tarcisio Not

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To investigate the role of endothelial PV-1 in patients with untreated celiac disease (CD)-associated liver injury. Materials & methods: PV-1 and PV-1 mRNA were measured in intestinal biopsies from untreated CD patients with elevated or normal alanine transaminase levels, controls, patients with inflammatory bowel disease and patients with toxic liver injury. Circulating PV-1 levels were also evaluated. Results: Circulating PV-1 levels were significantly increased in the serum of patients with CD-associated liver injury and reverted to normal following a gluten-free diet. Mucosal PV-1 and PV-1 mRNA were no different in patients with CD-associated liver injury. Conclusion: Serum but not mucosal PV-1 represents a marker of gluten-dependent liver injury and response to a gluten-free diet in patients with untreated CD.

Original languageEnglish
Pages (from-to)1675-1681
Number of pages7
JournalBiomarkers in Medicine
Volume14
Issue number18
DOIs
Publication statusPublished - Dec 2020

Keywords

  • celiac disease
  • diet
  • endothelium
  • gluten
  • gut-vascular barrier
  • plasmalemma vesicle-associated protein 1

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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