Circulating sex steroids and prostate cancer

Introducing the time-dependency theory

Andrea Salonia, Firas Abdollah, Umberto Capitanio, Nazareno Suardi, Andrea Gallina, Giulia Castagna, Maria Chiara Clementi, Alberto Briganti, Patrizio Rigatti, Francesco Montorsi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). Methods: Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels were analyzed according to either patient age, stratified into quartiles, or body mass index (BMI). Linear regression analyses tested the association between sex steroids and continuously coded patient age and BMI values. Results: No significant differences were found among age quartiles regarding serum tT levels and tT/E2 ratio. Conversely, E2 and SHBG levels significantly increased throughout time (all, p ≤ 0. 001). Total T did not linearly change according to continuously coded patient age; in contrast, E2 and SHBG linearly increased (all, p ≤ 0. 001), whereas tT/E2 decreased (p = 0. 016) with aging. Rate of hypogonadism significantly increased with aging (p = 0. 04). Total T, T/E2 ratio, and SHBG linearly decreased along with BMI increases (all p ≤ 0. 02), whereas serum E2 did not significantly change. Rate of hypogonadism significantly increased with BMI increases (p <0. 001). Conclusions: In contrast with longitudinal studies in the general male population, these data indirectly suggest that serum tT levels could be stable over time in PCa patients. This finding led to formulation of a "time-dependency theory", which postulates that the endocrine biology of prostate tissue is dependent on the exposure time at a given concentration of sex steroid, which, in turn, fluctuates throughout the lifespan of the individual.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalWorld Journal of Urology
Volume31
Issue number2
DOIs
Publication statusPublished - 2013

Fingerprint

Testosterone
Prostatic Neoplasms
Sex Hormone-Binding Globulin
Steroids
Body Mass Index
Hypogonadism
Serum
Hormones
Prostatectomy
Longitudinal Studies
Prostate
Estradiol
Linear Models
Regression Analysis
Population

Keywords

  • 17β estradiol
  • Prostate cancer
  • Radical prostatectomy
  • Sex hormone-binding globulin
  • Testosterone

ASJC Scopus subject areas

  • Urology

Cite this

Circulating sex steroids and prostate cancer : Introducing the time-dependency theory. / Salonia, Andrea; Abdollah, Firas; Capitanio, Umberto; Suardi, Nazareno; Gallina, Andrea; Castagna, Giulia; Clementi, Maria Chiara; Briganti, Alberto; Rigatti, Patrizio; Montorsi, Francesco.

In: World Journal of Urology, Vol. 31, No. 2, 2013, p. 267-273.

Research output: Contribution to journalArticle

Salonia, Andrea ; Abdollah, Firas ; Capitanio, Umberto ; Suardi, Nazareno ; Gallina, Andrea ; Castagna, Giulia ; Clementi, Maria Chiara ; Briganti, Alberto ; Rigatti, Patrizio ; Montorsi, Francesco. / Circulating sex steroids and prostate cancer : Introducing the time-dependency theory. In: World Journal of Urology. 2013 ; Vol. 31, No. 2. pp. 267-273.
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