Circulating SFRP5 levels are elevated in drug-naïve recently diagnosed type 2 diabetic patients as compared with prediabetic subjects and controls

Silvia Canivell, Sandra Rebuffat, Elena G. Ruano, Belchin Kostov, Antoni Sisó-Almirall, Anna Novials, Antonio Ceriello, Ramon Gomis

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Secreted frizzled-related protein 5 (SFRP5) has been linked to obesity. Results are conflicting regarding its association with type 2 diabetes (T2D) in humans. We aimed to investigate circulating SFRP5 in prediabetes and T2D and its potential association with parameters of insulin resistance and beta-cell function. Methods: We studied 70 drug-naïve T2D patients, 70 prediabetic subjects and 70 controls. All subjects were body mass index matched to the T2D patients and overweight or obese. SFRP5, hormones and cytokines levels were measured by ELISA. Results: Serum SFRP5 levels were elevated in T2D patients as compared with prediabetic subjects (median 15.6, interquartile range [9-24.5]ng/mL vs 9.8 [5-14.2]ng/mL, p

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalDiabetes/Metabolism Research and Reviews
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Adipokines
  • Diabetes mellitus, type 2
  • Obesity
  • Prediabetic state
  • Secreted frizzled-related protein 5, human

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Medicine(all)

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