Circulating soluble receptor for advanced glycation end product identifies patients with bicuspid aortic valve and associated aortopathies

Emanuela Branchetti, Joseph E. Bavaria, Juan B. Grau, Richard E. Shaw, Paolo Poggio, Eric K. Lai, Nimesh D. Desai, Joseph H. Gorman, Robert C. Gorman, Giovanni Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

Objective - A total of 30% to 50% of patients with bicuspid aortic valve (BAV) require surgery for aortic valve replacement (AVR), ascending aortic replacement (AA), or both. To prevent adverse aortic events, they are risk stratified using imperfect criteria based on imaging modalities. As a result, a significant number of dissections occur outside of the parameters suggested by the guidelines. Advanced glycation end products (AGEs) are associated with valve and vascular remodeling and trigger the release of a soluble receptor (soluble receptor for advanced glycation end product [sRAGE]). This study aims to characterize sRAGE as a diagnostic and risk-stratification tool for patients with BAV referred for surgery.

Approach and Results - sRAGE was measured in 135 patients (BAV, n=74; tricuspid aortic valve, n=61) meeting inclusion criteria from 338 enrolled patients undergoing AVR and AA. Univariate and multivariate analyses were performed. sRAGE level was significantly associated with the presence of BAV, independent of age, sex, and common risk factors for vascular disease (P2=0.007; P=0.51) or diameter/body surface area (R2=0.011; P=0.42).

Conclusions - These results show that elevated level of circulating sRAGE is associated with the presence of BAV and associated aortopathies, independent of aortic diameter.

Original languageEnglish
Pages (from-to)2349-2357
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume34
Issue number10
DOIs
Publication statusPublished - 2014

Keywords

  • Advanced glyosylation end-product receptor
  • Aortic aneurysm, thoracic
  • Bicuspid aortic valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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