TY - JOUR
T1 - Circulating T-cell subsets in Graves' disease
T2 - Differences between patients with active disease and in remission after 131J-therapy
AU - Canonica, Giorgio Walter
AU - Bagnasco, Marcello
AU - Ferrini, Silvano
AU - Biassoni, Paolo
AU - Giordano, Giulio
AU - Corte, Giorgio
PY - 1983
Y1 - 1983
N2 - In the present investigation some surface markers in peripheral blood T lymphocytes of patients with active Graves' disease and subjects in remission after 131I-therapy have been studied. We confirmed low TG levels in untreated patients and normal values in treated subjects. Increased percentages of DR+, MLR4+ (activated T cells), and 5 9+ (inducer-helper) T cells were detected in patients with active disease, thus indicating the presence of activated T cells and suggesting increased levels of helper T cells. High percentages of MLR4+ and 5 9+, but normal levels of DR+ were found in 131I-treated subjects. The different distribution of DR and MLR4 positivities on 5 9+ and 5 9- T cells confirm the different meaning of these two markers of the activation state. The imbalance of T-cell subsets found in 131I-treated subjects and the normal values observed in patients with hyperthyroidism due to toxic adenoma indicate that hyperthyroidism per se is not sufficient to explain the T-cell alterations. The possible meaning of these findings is discussed with respect to previous hypotheses on the pathogenesis of Graves' disease.
AB - In the present investigation some surface markers in peripheral blood T lymphocytes of patients with active Graves' disease and subjects in remission after 131I-therapy have been studied. We confirmed low TG levels in untreated patients and normal values in treated subjects. Increased percentages of DR+, MLR4+ (activated T cells), and 5 9+ (inducer-helper) T cells were detected in patients with active disease, thus indicating the presence of activated T cells and suggesting increased levels of helper T cells. High percentages of MLR4+ and 5 9+, but normal levels of DR+ were found in 131I-treated subjects. The different distribution of DR and MLR4 positivities on 5 9+ and 5 9- T cells confirm the different meaning of these two markers of the activation state. The imbalance of T-cell subsets found in 131I-treated subjects and the normal values observed in patients with hyperthyroidism due to toxic adenoma indicate that hyperthyroidism per se is not sufficient to explain the T-cell alterations. The possible meaning of these findings is discussed with respect to previous hypotheses on the pathogenesis of Graves' disease.
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U2 - 10.1016/0090-1229(83)90160-5
DO - 10.1016/0090-1229(83)90160-5
M3 - Article
C2 - 6223766
AN - SCOPUS:0020549717
VL - 28
SP - 265
EP - 271
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
SN - 0090-1229
IS - 2
ER -