Circulating T-cell subsets in Graves' disease: Differences between patients with active disease and in remission after 131J-therapy

Giorgio Walter Canonica, Marcello Bagnasco, Silvano Ferrini, Paolo Biassoni, Giulio Giordano, Giorgio Corte

Research output: Contribution to journalArticlepeer-review

Abstract

In the present investigation some surface markers in peripheral blood T lymphocytes of patients with active Graves' disease and subjects in remission after 131I-therapy have been studied. We confirmed low TG levels in untreated patients and normal values in treated subjects. Increased percentages of DR+, MLR4+ (activated T cells), and 5 9+ (inducer-helper) T cells were detected in patients with active disease, thus indicating the presence of activated T cells and suggesting increased levels of helper T cells. High percentages of MLR4+ and 5 9+, but normal levels of DR+ were found in 131I-treated subjects. The different distribution of DR and MLR4 positivities on 5 9+ and 5 9- T cells confirm the different meaning of these two markers of the activation state. The imbalance of T-cell subsets found in 131I-treated subjects and the normal values observed in patients with hyperthyroidism due to toxic adenoma indicate that hyperthyroidism per se is not sufficient to explain the T-cell alterations. The possible meaning of these findings is discussed with respect to previous hypotheses on the pathogenesis of Graves' disease.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalClinical Immunology and Immunopathology
Volume28
Issue number2
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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