Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis

Paolo Porcu, Costanza Emanueli, Elisa Desortes, Giovanni M. Marongiu, Franco Piredda, Lee Chao, Julie Chao, Paolo Madeddu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background-Vascular growth factors are upregulated in stroke patients, but it remains unknown if they correlate with carotid atherosclerosis. Methods and Results-A case-control study was conducted to determine: (1) possible association between biomarkers of angiogenesis or inflammation and carotid stenosis; and (2) the impact of revascularization on the same biomarkers. Circulating vascular endothelial growth factor (VEGF), basic fibroblast GF (bFGF), tissue kallikrein (tK), and high-sensitivity C-reactive protein (hs-CRP) were measured in 89 patients with carotid obstruction and 45 age-matched controls. Patients were stratified as

Original languageEnglish
Pages (from-to)1104-1110
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2004

Fingerprint

Tissue Kallikreins
Carotid Artery Diseases
Biomarkers
Carotid Stenosis
C-Reactive Protein
Vascular Endothelial Growth Factor A
Case-Control Studies
Intercellular Signaling Peptides and Proteins
Fibroblasts
Stroke
Inflammation

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Brain
  • Growth factors
  • Inflammation
  • Revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis. / Porcu, Paolo; Emanueli, Costanza; Desortes, Elisa; Marongiu, Giovanni M.; Piredda, Franco; Chao, Lee; Chao, Julie; Madeddu, Paolo.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 24, No. 6, 06.2004, p. 1104-1110.

Research output: Contribution to journalArticle

Porcu, Paolo ; Emanueli, Costanza ; Desortes, Elisa ; Marongiu, Giovanni M. ; Piredda, Franco ; Chao, Lee ; Chao, Julie ; Madeddu, Paolo. / Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2004 ; Vol. 24, No. 6. pp. 1104-1110.
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