Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis

Paolo Porcu, Costanza Emanueli, Elisa Desortes, Giovanni M. Marongiu, Franco Piredda, Lee Chao, Julie Chao, Paolo Madeddu

Research output: Contribution to journalArticlepeer-review


Background-Vascular growth factors are upregulated in stroke patients, but it remains unknown if they correlate with carotid atherosclerosis. Methods and Results-A case-control study was conducted to determine: (1) possible association between biomarkers of angiogenesis or inflammation and carotid stenosis; and (2) the impact of revascularization on the same biomarkers. Circulating vascular endothelial growth factor (VEGF), basic fibroblast GF (bFGF), tissue kallikrein (tK), and high-sensitivity C-reactive protein (hs-CRP) were measured in 89 patients with carotid obstruction and 45 age-matched controls. Patients were stratified as

Original languageEnglish
Pages (from-to)1104-1110
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number6
Publication statusPublished - Jun 2004


  • Angiogenesis
  • Atherosclerosis
  • Brain
  • Growth factors
  • Inflammation
  • Revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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