TY - JOUR
T1 - Circulating transforming growth factor-β and epidermal growth factor receptor as related to virus infection in liver carcinogenesis
AU - Divella, Rosa
AU - Daniele, Antonella
AU - Gadaleta, Cosimo
AU - Tufaro, Antonio
AU - Venneri, Maria Teresa
AU - Paradiso, Angelo
AU - Quaranta, Michele
PY - 2012/1
Y1 - 2012/1
N2 - Background: The aim of our study was to improve the detection of HCC by measuring alpha-fetoprotein (AFP) in addition to other molecular markers by estimating the plasma concentration of transforming growth factor beta (TGF-β) and epidermal growth factor receptor (EGFR). In particular, the role of hepatitis C and B viruses (HCV and HBV) infection was evaluated with relation to TGF-β and EGFR plasma concentration. Materials and Methods: Eighty-five patients with liver disease, 54 with hepatocellular carcinoma (HCC), 16 with liver metastasis (LM), 15 with liver cirrhosis (LC) and 30 healthy volunteers were evaluated. AFP, TGF-β and EGFR were detected with enzyme-linked immunoassay (ELISA) in plasma of all study participants. Results: The mean values of TGF-β and EGFR in all patients were much higher than in control group, p
AB - Background: The aim of our study was to improve the detection of HCC by measuring alpha-fetoprotein (AFP) in addition to other molecular markers by estimating the plasma concentration of transforming growth factor beta (TGF-β) and epidermal growth factor receptor (EGFR). In particular, the role of hepatitis C and B viruses (HCV and HBV) infection was evaluated with relation to TGF-β and EGFR plasma concentration. Materials and Methods: Eighty-five patients with liver disease, 54 with hepatocellular carcinoma (HCC), 16 with liver metastasis (LM), 15 with liver cirrhosis (LC) and 30 healthy volunteers were evaluated. AFP, TGF-β and EGFR were detected with enzyme-linked immunoassay (ELISA) in plasma of all study participants. Results: The mean values of TGF-β and EGFR in all patients were much higher than in control group, p
KW - EGFR in liver cancer
KW - HCV and HBV liver infection
KW - Hepatocellular carcinoma
KW - TGF-β in liver carcinogenesis
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M3 - Article
C2 - 22213299
AN - SCOPUS:84855711468
VL - 32
SP - 141
EP - 145
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 1
ER -