Circulating transforming growth factor-β and epidermal growth factor receptor as related to virus infection in liver carcinogenesis

Rosa Divella, Antonella Daniele, Cosimo Gadaleta, Antonio Tufaro, Maria Teresa Venneri, Angelo Paradiso, Michele Quaranta

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of our study was to improve the detection of HCC by measuring alpha-fetoprotein (AFP) in addition to other molecular markers by estimating the plasma concentration of transforming growth factor beta (TGF-β) and epidermal growth factor receptor (EGFR). In particular, the role of hepatitis C and B viruses (HCV and HBV) infection was evaluated with relation to TGF-β and EGFR plasma concentration. Materials and Methods: Eighty-five patients with liver disease, 54 with hepatocellular carcinoma (HCC), 16 with liver metastasis (LM), 15 with liver cirrhosis (LC) and 30 healthy volunteers were evaluated. AFP, TGF-β and EGFR were detected with enzyme-linked immunoassay (ELISA) in plasma of all study participants. Results: The mean values of TGF-β and EGFR in all patients were much higher than in control group, p

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalAnticancer Research
Volume32
Issue number1
Publication statusPublished - Jan 2012

Keywords

  • EGFR in liver cancer
  • HCV and HBV liver infection
  • Hepatocellular carcinoma
  • TGF-β in liver carcinogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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