Circulating tumor cells in prostate cancer diagnosis and monitoring: An appraisal of clinical potential

Giuseppe Galletti, Luigi Portella, Scott T. Tagawa, Brian J. Kirby, Paraskevi Giannakakou, David M. Nanus

Research output: Contribution to journalArticlepeer-review

Abstract

Circulating tumor cells (CTCs) have emerged as a viable solution to the lack of tumor tissue availability for patients with a variety of solid tumors, including prostate cancer. Different approaches have been used to capture this tumor cell population and several of these techniques have been used to assess the potential role of CTCs as a biological marker to predict treatment efficacy and clinical outcome. CTCs are now considered a strong tool to understand the molecular characteristics of prostate cancer, and to be used and analyzed as a 'liquid biopsy' in the attempt to grasp the biological portrait of the disease in the individual patient.

Original languageEnglish
Pages (from-to)389-402
Number of pages14
JournalMolecular Diagnosis and Therapy
Volume18
Issue number4
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Medicine(all)
  • Pharmacology

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