Circulating tumor cells in the adenocarcinoma of the esophagus

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Circulating tumor cells (CTCs) are elements of indisputable significance as they seem to be responsible for the onset of metastasis. Despite this, research into CTCs and their clinical application have been hindered by their rarity and heterogeneity at the molecular and cellular level, and also by a lack of technical standardization. Esophageal adenocarcinoma (EAC) is a highly aggressive cancer that is often diagnosed at an advanced stage. Its incidence has increased so much in recent years that new diagnostic, prognostic and predictive biomarkers are urgently needed. Preliminary findings suggest that CTCs could represent an effective, non-invasive, real-time assessable biomarker in all stages of EAC. This review provides an overview of EAC and CTC characteristics and reports the main research results obtained on CTCs in this setting. The need to carry out further basic and translational research in this area to confirm the clinical usefulness of CTCs and to provide oncologists with a tool to improve therapeutic strategies for EAC patients was herein highlighted.

Original languageEnglish
Article number1266
JournalInternational Journal of Molecular Sciences
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 4 2016

Fingerprint

Circulating Neoplastic Cells
esophagus
Tumors
tumors
Cells
Adenocarcinoma
biomarkers
Biomarkers
Translational Medical Research
standardization
metastasis
Research
Standardization
Adenocarcinoma Of Esophagus
incidence
cancer
Neoplasm Metastasis
Incidence
cells
Neoplasms

Keywords

  • Circulating tumor cells
  • Esophagus adenocarcinoma
  • Liquid biopsy

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Circulating tumor cells in the adenocarcinoma of the esophagus. / Gallerani, Giulia; Fabbri, Francesco.

In: International Journal of Molecular Sciences, Vol. 17, No. 8, 1266, 04.08.2016.

Research output: Contribution to journalReview article

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