Circulating tumour cells in breast cancer at the diagnosis are associated with lymph node involvement, tumour size and negative ER status

P. Ferro, M. C. Franceschini, B. Bacigalupo, P. Dessanti, V. Fontana, D. Gianquinto, A. Morabito, M. P. Pistillo, F. Fedeli, S. Roncella

Research output: Contribution to journalArticle

Abstract

We investigated the association of circulating tumor cells (CTC) with poor prognostic markers in breast cancer (BC) at time of diagnosis. Peripheral blood (PB) samples from 190 patients with invasive BC, 12 patients with in situ BC, before theraphy and/or surgery, and 330 from patients without BC were tested for CTCs by RT-PCR for human mammaglobin (hMAM). hMAM was expressed only in PB of invasive BC (9.5%) and a significant correlation was found between CTCs with lymph node involvement, tumour size and negative ER. We conclude that CTC detention in invasive BC may be an additional poor prognostic indicator.

Original languageEnglish
Pages (from-to)135-136
Number of pages2
JournalJournal of Biological Research (Italy)
Volume84
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

Keywords

  • Circulating tumour cells
  • Human mammaglobin
  • RT-PCR

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Plant Science
  • Biochemistry, medical

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