Abstract
| Original language | English |
|---|---|
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 61 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- Antibiotic resistance
- Citrobacter freundii
- IncX3
- KPC
- KPC-3
- bacterial enzyme
- beta lactamase
- beta lactamase KPC 3
- nucleotide
- unclassified drug
- Article
- bacterial strain
- bacterium isolation
- Italy
- nonhuman
- nucleotide sequence
- plasmid
- priority journal
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Circulation of blaKPC-3-carrying IncX3 plasmids among Citrobacter freundii isolates in an Italian Hospital. / Venditti, C.; Fortini, D.; Villa, L.; Vulcano, A.; D’Arezzo, S.; Capone, A.; Petrosillo, N.; Nisii, C.; Carattoli, A.; Di Caro, A.
In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 8, 2017.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Circulation of blaKPC-3-carrying IncX3 plasmids among Citrobacter freundii isolates in an Italian Hospital
AU - Venditti, C.
AU - Fortini, D.
AU - Villa, L.
AU - Vulcano, A.
AU - D’Arezzo, S.
AU - Capone, A.
AU - Petrosillo, N.
AU - Nisii, C.
AU - Carattoli, A.
AU - Di Caro, A.
N1 - Cited By :1 Export Date: 16 April 2018 CODEN: AMACC Correspondence Address: Di Caro, A.; National Institute for Infectious Diseases (INMI) L. SpallanzaniItaly; email: antonino.dicaro@inmi.it Molecular Sequence Numbers: GENBANK: KY659387:KY659388; Chemicals/CAS: beta lactamase, 9073-60-3 References: Giani, T., Pini, B., Arena, F., Conte, V., Bracco, S., Migliavacca, R., Pantosti, A., Rossolini, G.M., Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: Results of the first countrywide survey, 15 May to 30 June 2011 (2013) Euro Surveill, 30 (22), p. 18. , http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId20489; Munoz-Price, L.S., Poirel, L., Bonomo, R.A., Schwaber, M.J., Daikos, G.L., Cormican, M., Cornaglia, G., Quinn, J.P., Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases (2013) Lancet Infect Dis, 13, pp. 785-796. , https://doi.org/10.1016/S1473-3099(13)70190-7; Naas, T., Cuzon, G., Villegas, M.V., Lartigue, M.F., Quinn, J.P., Nordmann, P., Genetic structures at the origin of acquisition of the beta-lactamase blaKPC gene (2008) Antimicrob Agents Chemother, 52, pp. 1257-1263. , https://doi.org/10.1128/AAC.01451-07; Zhang, R., Yang, L., Cai, J.C., Zhou, H.W., Chen, G.X., High-level carbapenem resistance in a Citrobacter freundii clinical isolate is due to a combination of KPC-2 production and decreased porin expression (2008) J Med Microbiol, 57, pp. 332-337. , https://doi.org/10.1099/jmm.0.47576-0; Adler, A., Khabra, E., Paikin, S., Carmeli, Y., Dissemination of the blaKPC gene by clonal spread and horizontal gene transfer: Comparative study of incidence and molecular mechanisms (2016) J Antimicrob Chemother, 71, pp. 2143-2146. , https://doi.org/10.1093/jac/dkw106; Ribeiro, T.G., Novais, Â., Branquinho, R., Machado, E., Peixe, L., Phylogeny and comparative genomics unveil independent diversification trajectories of qnrB and genetic platforms within particular Citrobacter species (2015) Antimicrob Agents Chemother, 59, pp. 5951-5958. , https://doi.org/10.1128/AAC.00027-15; Ribeiro, T.G., Clermont, D., Branquinho, R., Machado, E., Peixe, L., Brisse, S., Citrobacter europaeus sp. Nov., isolated from water and human faecal samples (2017) Int J Syst Evol Microbiol, 67, pp. 170-173. , https://doi.org/10.1099/ijsem.0.001606; (2015) M07-A10. Methods for Dilution Antimicrobial Susceptibility Test for Bacteria That Grow Aerobically; Approved Standard, , Clinical and Laboratory Standards Institute (CLSI). 10th ed. CLSI, Wayne, PA; Bai, L., Xia, S., Lan, R., Liu, L., Ye, C., Wang, Y., Jin, D., Xu, J., Isolation and characterization of cytotoxic, aggregative Citrobacter freundii (2012) Plos One, 7. , https://doi.org/10.1371/journal.pone.0033054; Wirth, T., Falush, D., Lan, R., Colles, F., Mensa, P., Wieler, L.H., Karch, H., Achtman, M., Sex and virulence in Escherichia coli: An evolutionary perspective (2006) Mol Microbiol, 60, pp. 1136-1151. , https://doi.org/10.1111/j.1365-2958.2006.05172.x; Lunha, K., Chanawong, A., Lulitanond, A., Wilailuckana, C., Charoensri, N., Wonglakorn, L., Saenjamla, P., Chetchotisakd, P., High-level carbapenem-resistant OXA-48-producing Klebsiella pneumoniae with a novel OmpK36 variant and low-level, carbapenem-resistant, non-porin-deficient, OXA-181-producing Escherichia coli from Thailand (2016) Diagn Microbiol Infect Dis, 85, pp. 221-226. , https://doi.org/10.1016/j.diagmicrobio.2016.03.009; Dortet, L., Poirel, L., Anguel, N., Nordmann, P., New Delhi metallo-β-lactamase 4-producing Escherichia coli in Cameroon (2012) Emerg Infect Dis, 18, pp. 1540-1542. , https://doi.org/10.3201/eid1809.120011; Peirano, G., Lascols, C., Hackel, M., Hoban, D.J., Pitout, J.D., Molecular epidemiology of Enterobacteriaceae that produce VIMs and IMPs from the SMART surveillance program (2014) Diagn Microbiol Infect Dis, 78, pp. 277-281. , https://doi.org/10.1016/j.diagmicrobio.2013.11.024; Poirel, L., Walsh, T.R., Cuvillier, V., Nordmann, P., Multiplex PCR for detection of acquired carbapenemase genes (2011) Diagn Microbiol Infect Dis, 70, pp. S119-S123. , https://doi.org/10.1016/j.diagmicrobio.2010.12.002; Mabilat, C., Goussard, S., Sougakoff, W., Spencer, R.C., Courvalin, P., Direct sequencing of the amplified structural gene and promoter for the extended-broad-spectrum beta-lactamase TEM-9 (RHH-1) of Klebsiella pneumoniae (1990) Plasmid, 23, pp. S27-S34. , https://doi.org/10.1016/0147-619X(90)90041-A; Carattoli, A., Bertini, A., Villa, L., Falbo, V., Hopkins, K.L., Threlfall, E.J., Identification of plasmids by PCR-based replicon typing (2005) J Microbiol Methods, 63, pp. S219-S228. , https://doi.org/10.1016/j.mimet.2005.03.018; Tritt, A., Eisen, J.A., Facciotti, M.T., Darling, A.E., An integrated pipeline for de novo assembly of microbial genomes (2012) Plos One, 7. , https://doi.org/10.1371/journal.pone.0042304; García-Fernández, A., Villa, L., Carta, C., Venditti, C., Giordano, A., Venditti, M., Mancini, C., Carattoli, A., Klebsiella pneumoniae ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/OmpK35 porin variants (2012) Antimicrob Agents Chemother, 56, pp. 2143-2145. , https://doi.org/10.1128/AAC.05308-11; Ho, P.L., Cheung, Y.Y., Lo, W.U., Li, Z., Chow, K.H., Lin, C.H., Chan, J.F., Cheng, V.C., Molecular characterization of an atypical IncX3 plasmid pKPC-NY79 carrying blaKPC-2 in a Klebsiella pneumoniae (2013) Curr Microbiol, 67, pp. 493-498. , https://doi.org/10.1007/s00284-013-0398-2; Ho, P.L., Li, Z., Lo, W.U., Cheung, Y.Y., Lin, C.H., Sham, P.C., Cheng, V.C., Chow, K.H., Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China (2012) Emerg Microbes Infect, 1, p. e39. , https://doi.org/10.1038/emi.2012.37; Feng, J., Qiu, Y., Yin, Z., Chen, W., Yang, H., Yang, W., Wang, J., Zhou, D., Coexistence of a novel KPC-2-encoding MDR plasmid and an NDM-1-encoding pNDM-HN380-like plasmid in a clinical isolate of Citrobacter freundii (2015) J Antimicrob Chemother, 70, pp. 2987-2991. , https://doi.org/10.1093/jac/dkv232
PY - 2017
Y1 - 2017
N2 - Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes. © 2017 American Society for Microbiology. All Rights Reserved.
AB - Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes. © 2017 American Society for Microbiology. All Rights Reserved.
KW - Antibiotic resistance
KW - Citrobacter freundii
KW - IncX3
KW - KPC
KW - KPC-3
KW - bacterial enzyme
KW - beta lactamase
KW - beta lactamase KPC 3
KW - nucleotide
KW - unclassified drug
KW - Article
KW - bacterial strain
KW - bacterium isolation
KW - Italy
KW - nonhuman
KW - nucleotide sequence
KW - plasmid
KW - priority journal
U2 - 10.1128/AAC.00505-17
DO - 10.1128/AAC.00505-17
M3 - Article
VL - 61
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 8
ER -