Circulation of blaKPC-3-carrying IncX3 plasmids among Citrobacter freundii isolates in an Italian Hospital

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Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes. © 2017 American Society for Microbiology. All Rights Reserved.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Issue number8
Publication statusPublished - 2017



  • Antibiotic resistance
  • Citrobacter freundii
  • IncX3
  • KPC
  • KPC-3
  • bacterial enzyme
  • beta lactamase
  • beta lactamase KPC 3
  • nucleotide
  • unclassified drug
  • Article
  • bacterial strain
  • bacterium isolation
  • Italy
  • nonhuman
  • nucleotide sequence
  • plasmid
  • priority journal

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