Circulation of blaKPC-3-carrying IncX3 plasmids among Citrobacter freundii isolates in an Italian Hospital

Carolina Venditti; Daniela Fortini; Laura Villa; Antonella Vulcano; Silvia D’Arezzo; Alessandro Capone; Nicola Petrosillo; Carla Nisii; Alessandra Carattoli; Antonino Di Caro

doi:10.1128/AAC.00505-17

Circulation of bla_KPC-3-carrying IncX3 plasmids among Citrobacter freundii isolates in an Italian Hospital

Carolina Venditti, Daniela Fortini, Laura Villa, Antonella Vulcano, Silvia D’Arezzo, Alessandro Capone, Nicola Petrosillo, Carla Nisii, Alessandra Carattoli, Antonino Di Caro

Research output: Contribution to journal › Article › peer-review

Abstract

Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. bla_KPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes.

Original language	English
Article number	e00505
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00505-17
Publication status	Published - Aug 1 2017

Keywords

Antibiotic resistance
Citrobacter freundii
IncX3
KPC
KPC-3

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.00505-17

Cite this

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title = "Circulation of blaKPC-3-carrying IncX3 plasmids among Citrobacter freundii isolates in an Italian Hospital",

abstract = "Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes.",

keywords = "Antibiotic resistance, Citrobacter freundii, IncX3, KPC, KPC-3",

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T1 - Circulation of blaKPC-3-carrying IncX3 plasmids among Citrobacter freundii isolates in an Italian Hospital

AU - Venditti, Carolina

AU - Fortini, Daniela

AU - Villa, Laura

AU - Vulcano, Antonella

AU - D’Arezzo, Silvia

AU - Capone, Alessandro

AU - Petrosillo, Nicola

AU - Nisii, Carla

AU - Carattoli, Alessandra

AU - Di Caro, Antonino

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes.

AB - Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes.

KW - Antibiotic resistance

KW - Citrobacter freundii

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KW - KPC

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