Circulatory reflexes from carotid and extracarotid baroreceptor areas in man

G. Mancia, A. Ferrari, L. Gregorini, R. Valentini, J. Ludbrook, A. Zanchetti

Research output: Contribution to journalArticle

Abstract

The carotid sinus baroreceptor reflex was studied in 11 normotensive subjects, using a variable pressure neck chamber and correcting for imperfect pressure transmission to the carotid sinus. Decreased carotid baroreceptor stimulation caused a sustained rise in arterial pressure, and increased carotid baroreceptor stimulation caused a sustained fall. The responses were in linear relation to the stimulus, and, after reaching the steady state, greater for the reduced than for the increased baroreceptor stimulation. Thus the carotid sinus baroreceptor reflex of the normotensive man is an effective antihypotensive and antihypertensive feedback system, though the former function may have more sensitivity. The increased and decreased baroreceptor stimulation by the neck chamber also caused bradycardia and tachycardia which were modest in magnitude and often transient. In eight subjects the reflex changes in heart rate induced by the neck chamber were compared with those induced by altering transmural pressure not merely at the carotid sinus but throughout the arterial tree (injection of phenylephrine and trinitroglycerin). The slopes of these relations were 3 times as great in the latter circumstance. Thus the carotid baroreceptors play a lesser role in heart rate control than do extracarotid baroreceptors.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalCirculation Research
Volume41
Issue number3
Publication statusPublished - 1977

Fingerprint

Pressoreceptors
Reflex
Carotid Sinus
Neck
Baroreflex
Pressure
Heart Rate
Phenylephrine
Bradycardia
Tachycardia
Antihypertensive Agents
Arterial Pressure
Injections

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mancia, G., Ferrari, A., Gregorini, L., Valentini, R., Ludbrook, J., & Zanchetti, A. (1977). Circulatory reflexes from carotid and extracarotid baroreceptor areas in man. Circulation Research, 41(3), 309-315.

Circulatory reflexes from carotid and extracarotid baroreceptor areas in man. / Mancia, G.; Ferrari, A.; Gregorini, L.; Valentini, R.; Ludbrook, J.; Zanchetti, A.

In: Circulation Research, Vol. 41, No. 3, 1977, p. 309-315.

Research output: Contribution to journalArticle

Mancia, G, Ferrari, A, Gregorini, L, Valentini, R, Ludbrook, J & Zanchetti, A 1977, 'Circulatory reflexes from carotid and extracarotid baroreceptor areas in man', Circulation Research, vol. 41, no. 3, pp. 309-315.
Mancia G, Ferrari A, Gregorini L, Valentini R, Ludbrook J, Zanchetti A. Circulatory reflexes from carotid and extracarotid baroreceptor areas in man. Circulation Research. 1977;41(3):309-315.
Mancia, G. ; Ferrari, A. ; Gregorini, L. ; Valentini, R. ; Ludbrook, J. ; Zanchetti, A. / Circulatory reflexes from carotid and extracarotid baroreceptor areas in man. In: Circulation Research. 1977 ; Vol. 41, No. 3. pp. 309-315.
@article{93911badd90b4ae88829312dfa6396d5,
title = "Circulatory reflexes from carotid and extracarotid baroreceptor areas in man",
abstract = "The carotid sinus baroreceptor reflex was studied in 11 normotensive subjects, using a variable pressure neck chamber and correcting for imperfect pressure transmission to the carotid sinus. Decreased carotid baroreceptor stimulation caused a sustained rise in arterial pressure, and increased carotid baroreceptor stimulation caused a sustained fall. The responses were in linear relation to the stimulus, and, after reaching the steady state, greater for the reduced than for the increased baroreceptor stimulation. Thus the carotid sinus baroreceptor reflex of the normotensive man is an effective antihypotensive and antihypertensive feedback system, though the former function may have more sensitivity. The increased and decreased baroreceptor stimulation by the neck chamber also caused bradycardia and tachycardia which were modest in magnitude and often transient. In eight subjects the reflex changes in heart rate induced by the neck chamber were compared with those induced by altering transmural pressure not merely at the carotid sinus but throughout the arterial tree (injection of phenylephrine and trinitroglycerin). The slopes of these relations were 3 times as great in the latter circumstance. Thus the carotid baroreceptors play a lesser role in heart rate control than do extracarotid baroreceptors.",
author = "G. Mancia and A. Ferrari and L. Gregorini and R. Valentini and J. Ludbrook and A. Zanchetti",
year = "1977",
language = "English",
volume = "41",
pages = "309--315",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Circulatory reflexes from carotid and extracarotid baroreceptor areas in man

AU - Mancia, G.

AU - Ferrari, A.

AU - Gregorini, L.

AU - Valentini, R.

AU - Ludbrook, J.

AU - Zanchetti, A.

PY - 1977

Y1 - 1977

N2 - The carotid sinus baroreceptor reflex was studied in 11 normotensive subjects, using a variable pressure neck chamber and correcting for imperfect pressure transmission to the carotid sinus. Decreased carotid baroreceptor stimulation caused a sustained rise in arterial pressure, and increased carotid baroreceptor stimulation caused a sustained fall. The responses were in linear relation to the stimulus, and, after reaching the steady state, greater for the reduced than for the increased baroreceptor stimulation. Thus the carotid sinus baroreceptor reflex of the normotensive man is an effective antihypotensive and antihypertensive feedback system, though the former function may have more sensitivity. The increased and decreased baroreceptor stimulation by the neck chamber also caused bradycardia and tachycardia which were modest in magnitude and often transient. In eight subjects the reflex changes in heart rate induced by the neck chamber were compared with those induced by altering transmural pressure not merely at the carotid sinus but throughout the arterial tree (injection of phenylephrine and trinitroglycerin). The slopes of these relations were 3 times as great in the latter circumstance. Thus the carotid baroreceptors play a lesser role in heart rate control than do extracarotid baroreceptors.

AB - The carotid sinus baroreceptor reflex was studied in 11 normotensive subjects, using a variable pressure neck chamber and correcting for imperfect pressure transmission to the carotid sinus. Decreased carotid baroreceptor stimulation caused a sustained rise in arterial pressure, and increased carotid baroreceptor stimulation caused a sustained fall. The responses were in linear relation to the stimulus, and, after reaching the steady state, greater for the reduced than for the increased baroreceptor stimulation. Thus the carotid sinus baroreceptor reflex of the normotensive man is an effective antihypotensive and antihypertensive feedback system, though the former function may have more sensitivity. The increased and decreased baroreceptor stimulation by the neck chamber also caused bradycardia and tachycardia which were modest in magnitude and often transient. In eight subjects the reflex changes in heart rate induced by the neck chamber were compared with those induced by altering transmural pressure not merely at the carotid sinus but throughout the arterial tree (injection of phenylephrine and trinitroglycerin). The slopes of these relations were 3 times as great in the latter circumstance. Thus the carotid baroreceptors play a lesser role in heart rate control than do extracarotid baroreceptors.

UR - http://www.scopus.com/inward/record.url?scp=0017730218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017730218&partnerID=8YFLogxK

M3 - Article

C2 - 408046

AN - SCOPUS:0017730218

VL - 41

SP - 309

EP - 315

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 3

ER -