Cirrhosis

Diagnosis with sonographic study of the liver surface

A. Di Lelio, C. Cestari, A. Lomazzi, L. Beretta

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

To find an objective sonographic sign of cirrhosis, the authors used a small-parts probe to examine the liver surfae for irregularities that corresponded to those of nodular regeneration. Fifty healthy subjects were examined to assess the pattern of a sonographically normal-appearing liver surface. A second group of 75 patients, mainly with suspected diffuse chronic liver disease, was examined with particular attention to the most commonly described sonographic signs of cirrhosis, and laparoscopy and biopsy were also performed. The liver surface was examined in a third group of 225 patients with cancer in whom metastases had been demonstrated sonographically. A diagnosis of cirrhosis was made with sonography when surface irregularities were observed that were comparable to the anatomic abnormalities of a cirrhotic liver surface. An examination of the liver surface gave the best diagnostic rate for cirrhosis (88%). There were seven false-negative results, but in five of them no surface nodularity could be seen at laparoscopy, and the diagnosis was made only on the basis of histologic studies; there was one false-positive result. This study indicated that ultrasonography might be a reliable method to follow up patients with chronic liver disease that may progress to cirrhosis.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalRadiology
Volume172
Issue number2
Publication statusPublished - 1989

Fingerprint

Fibrosis
Liver
Laparoscopy
Liver Diseases
Ultrasonography
Chronic Disease
Regeneration
Healthy Volunteers
Neoplasm Metastasis
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Di Lelio, A., Cestari, C., Lomazzi, A., & Beretta, L. (1989). Cirrhosis: Diagnosis with sonographic study of the liver surface. Radiology, 172(2), 389-392.

Cirrhosis : Diagnosis with sonographic study of the liver surface. / Di Lelio, A.; Cestari, C.; Lomazzi, A.; Beretta, L.

In: Radiology, Vol. 172, No. 2, 1989, p. 389-392.

Research output: Contribution to journalArticle

Di Lelio, A, Cestari, C, Lomazzi, A & Beretta, L 1989, 'Cirrhosis: Diagnosis with sonographic study of the liver surface', Radiology, vol. 172, no. 2, pp. 389-392.
Di Lelio A, Cestari C, Lomazzi A, Beretta L. Cirrhosis: Diagnosis with sonographic study of the liver surface. Radiology. 1989;172(2):389-392.
Di Lelio, A. ; Cestari, C. ; Lomazzi, A. ; Beretta, L. / Cirrhosis : Diagnosis with sonographic study of the liver surface. In: Radiology. 1989 ; Vol. 172, No. 2. pp. 389-392.
@article{908ed23c3c1c4dd5a50c902f70ca457c,
title = "Cirrhosis: Diagnosis with sonographic study of the liver surface",
abstract = "To find an objective sonographic sign of cirrhosis, the authors used a small-parts probe to examine the liver surfae for irregularities that corresponded to those of nodular regeneration. Fifty healthy subjects were examined to assess the pattern of a sonographically normal-appearing liver surface. A second group of 75 patients, mainly with suspected diffuse chronic liver disease, was examined with particular attention to the most commonly described sonographic signs of cirrhosis, and laparoscopy and biopsy were also performed. The liver surface was examined in a third group of 225 patients with cancer in whom metastases had been demonstrated sonographically. A diagnosis of cirrhosis was made with sonography when surface irregularities were observed that were comparable to the anatomic abnormalities of a cirrhotic liver surface. An examination of the liver surface gave the best diagnostic rate for cirrhosis (88{\%}). There were seven false-negative results, but in five of them no surface nodularity could be seen at laparoscopy, and the diagnosis was made only on the basis of histologic studies; there was one false-positive result. This study indicated that ultrasonography might be a reliable method to follow up patients with chronic liver disease that may progress to cirrhosis.",
author = "{Di Lelio}, A. and C. Cestari and A. Lomazzi and L. Beretta",
year = "1989",
language = "English",
volume = "172",
pages = "389--392",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Cirrhosis

T2 - Diagnosis with sonographic study of the liver surface

AU - Di Lelio, A.

AU - Cestari, C.

AU - Lomazzi, A.

AU - Beretta, L.

PY - 1989

Y1 - 1989

N2 - To find an objective sonographic sign of cirrhosis, the authors used a small-parts probe to examine the liver surfae for irregularities that corresponded to those of nodular regeneration. Fifty healthy subjects were examined to assess the pattern of a sonographically normal-appearing liver surface. A second group of 75 patients, mainly with suspected diffuse chronic liver disease, was examined with particular attention to the most commonly described sonographic signs of cirrhosis, and laparoscopy and biopsy were also performed. The liver surface was examined in a third group of 225 patients with cancer in whom metastases had been demonstrated sonographically. A diagnosis of cirrhosis was made with sonography when surface irregularities were observed that were comparable to the anatomic abnormalities of a cirrhotic liver surface. An examination of the liver surface gave the best diagnostic rate for cirrhosis (88%). There were seven false-negative results, but in five of them no surface nodularity could be seen at laparoscopy, and the diagnosis was made only on the basis of histologic studies; there was one false-positive result. This study indicated that ultrasonography might be a reliable method to follow up patients with chronic liver disease that may progress to cirrhosis.

AB - To find an objective sonographic sign of cirrhosis, the authors used a small-parts probe to examine the liver surfae for irregularities that corresponded to those of nodular regeneration. Fifty healthy subjects were examined to assess the pattern of a sonographically normal-appearing liver surface. A second group of 75 patients, mainly with suspected diffuse chronic liver disease, was examined with particular attention to the most commonly described sonographic signs of cirrhosis, and laparoscopy and biopsy were also performed. The liver surface was examined in a third group of 225 patients with cancer in whom metastases had been demonstrated sonographically. A diagnosis of cirrhosis was made with sonography when surface irregularities were observed that were comparable to the anatomic abnormalities of a cirrhotic liver surface. An examination of the liver surface gave the best diagnostic rate for cirrhosis (88%). There were seven false-negative results, but in five of them no surface nodularity could be seen at laparoscopy, and the diagnosis was made only on the basis of histologic studies; there was one false-positive result. This study indicated that ultrasonography might be a reliable method to follow up patients with chronic liver disease that may progress to cirrhosis.

UR - http://www.scopus.com/inward/record.url?scp=0024354739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024354739&partnerID=8YFLogxK

M3 - Article

VL - 172

SP - 389

EP - 392

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -