Cirrhosis of the liver - A regenerative process

Francesco Callea, Massimo Brisigotti, Giovanna Fabbretti, R. Sciot, P. Van Eyken, M. Favret

Research output: Contribution to journalArticle

Abstract

The ancient story of Prometheus, chained to a rock for defying Zeus by stealing fire from Mount Olympus and subjected to daily tearing at his liver by an eagle, attests to the early recognition of the extraordinary regenerative capacity of the human liver. This process had remained an intriguing mystery over the millennia. In the last 20 years, following the pioneering work of Bucher (1) and Moolten et al (2), there has been an explosion of research that has clarified some of the mechanisms underlying the process of hepatic regeneration. Regeneration implies proliferation and regeneration. After the fetal and postnatal growth of the liver is completed, hepatocytes no longer proliferate actively, but they can proliferate in response to cell death or loss (3). Hepatocyte growth responses are of particular research interest because they occur in vivo and involve cells that are normally quiescent. Hepatic regeneration constitutes a highly regulated process that is best shown by the arrest of liver growth following a partial hepatectomy precisely at the moment the hepatic mass reaches the mass of the original intact liver (3). This suggests that hepatic regeneration after a partial hepatectomy is a strictly regulated nonautonomous growth process that is controlled by the same factors that are responsible for the determination and maintenance of hepatic mass in a normal individual. In response to a partial hepatectomy, hepatocytes enter the cell cycle and progress to DNA synthesis and replication but only in number sufficient to restore the hepatic mass. The regeneration response is both synchronized and universal in that it affects all intrahepatic cell lines, including nonparenchymal cells. The first part of the present paper deals with a review of the concepts related to the regulation of growth and regeneration following liver injury. This is followed by discussion of the process of hyperplasia and neoplasia seen in cirrhosis. The second part of this work deals with a new histopathological method used to identify hepatocellular carcinoma (HCC), which is based upon a consideration of dynamic criteria and the lessons learned from a human disease process, alpha-1-antitrypsin (AAT) deficiency.

Original languageEnglish
Pages (from-to)1287-1293
Number of pages7
JournalDigestive Diseases and Sciences
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 1991

Fingerprint

Liver Cirrhosis
Liver
Regeneration
Hepatectomy
Hepatocytes
Growth
alpha 1-Antitrypsin Deficiency
Theft
Eagles
Liver Regeneration
Explosions
Fetal Development
DNA Replication
Research
Hyperplasia
Hepatocellular Carcinoma
Cell Cycle
Fibrosis
Cell Death
Maintenance

Keywords

  • alpha-1-antitrypsin deficiency
  • cirrhosis
  • hepatic regeneration
  • hepatocellular carcinoma
  • hyperplastic nodules

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Callea, F., Brisigotti, M., Fabbretti, G., Sciot, R., Van Eyken, P., & Favret, M. (1991). Cirrhosis of the liver - A regenerative process. Digestive Diseases and Sciences, 36(9), 1287-1293. https://doi.org/10.1007/BF01307524

Cirrhosis of the liver - A regenerative process. / Callea, Francesco; Brisigotti, Massimo; Fabbretti, Giovanna; Sciot, R.; Van Eyken, P.; Favret, M.

In: Digestive Diseases and Sciences, Vol. 36, No. 9, 09.1991, p. 1287-1293.

Research output: Contribution to journalArticle

Callea, F, Brisigotti, M, Fabbretti, G, Sciot, R, Van Eyken, P & Favret, M 1991, 'Cirrhosis of the liver - A regenerative process', Digestive Diseases and Sciences, vol. 36, no. 9, pp. 1287-1293. https://doi.org/10.1007/BF01307524
Callea F, Brisigotti M, Fabbretti G, Sciot R, Van Eyken P, Favret M. Cirrhosis of the liver - A regenerative process. Digestive Diseases and Sciences. 1991 Sep;36(9):1287-1293. https://doi.org/10.1007/BF01307524
Callea, Francesco ; Brisigotti, Massimo ; Fabbretti, Giovanna ; Sciot, R. ; Van Eyken, P. ; Favret, M. / Cirrhosis of the liver - A regenerative process. In: Digestive Diseases and Sciences. 1991 ; Vol. 36, No. 9. pp. 1287-1293.
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