Cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

Cristina Airoldi, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Artur Silva, Francesco Nicotra, Barbara La Ferla

Research output: Contribution to journalArticle

Abstract

A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with Aβ peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.

Original languageEnglish
Pages (from-to)10266-10268
Number of pages3
JournalChemical Communications
Volume47
Issue number37
DOIs
Publication statusPublished - Oct 7 2011

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Benzopyrans
Molecular mechanics
Amyloid
Peptides
Molecular dynamics
Ligands
Nuclear magnetic resonance
Computer simulation
Experiments

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands. / Airoldi, Cristina; Cardona, Francisco; Sironi, Erika; Colombo, Laura; Salmona, Mario; Silva, Artur; Nicotra, Francesco; La Ferla, Barbara.

In: Chemical Communications, Vol. 47, No. 37, 07.10.2011, p. 10266-10268.

Research output: Contribution to journalArticle

Airoldi, C, Cardona, F, Sironi, E, Colombo, L, Salmona, M, Silva, A, Nicotra, F & La Ferla, B 2011, 'Cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands', Chemical Communications, vol. 47, no. 37, pp. 10266-10268. https://doi.org/10.1039/c1cc13046c
Airoldi, Cristina ; Cardona, Francisco ; Sironi, Erika ; Colombo, Laura ; Salmona, Mario ; Silva, Artur ; Nicotra, Francesco ; La Ferla, Barbara. / Cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands. In: Chemical Communications. 2011 ; Vol. 47, No. 37. pp. 10266-10268.
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