Cisapride use during human pregnancy: A prospective, controlled multicenter study

Benoit Bailey, Antonio Addis, Amy Lee, Kinjal Sanghvi, Pierpaolo Mastroiacovo, Teresa Mazzone, Maurizo Bonati, Cinzia Paolini, Hanneke Garbis, Thierry Val, Carolina F M De Souza, Doren Matsui, Amy Stein Schechtman, Beth Conover, Melissa Lau, Gideon Koren

Research output: Contribution to journalArticlepeer-review


The objective of this prospective multicenter study was to determine whether cisapride is associated with increased risk of malformations, spontaneous abortions, or decreased birthweight when used during pregnancy. Cases were paired for age, smoking, and alcohol consumption with controls exposed to nonteratogens, as well as with disease-paired controls. One hundred and twenty-nine pregnant women were exposed to cisapride during pregnancy, including 88 during the period of fetal organogenesis. There were no differences in maternal history, birthweight, gestational age at delivery, and rates of livebirths, spontaneous or therapeutic abortions, fetal distress, and major or minor malformations among groups. It is concluded that exposure to cisapride during pregnancy is not associated with a major increased risk of malformations or spontaneous abortions or with decreased birthweight.

Original languageEnglish
Pages (from-to)1848-1852
Number of pages5
JournalDigestive Diseases and Sciences
Issue number9
Publication statusPublished - 1997


  • Cisapride
  • Drug-induced abnormality
  • Human
  • Pregnancy

ASJC Scopus subject areas

  • Gastroenterology


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