Abstract
In this study 32 newly diagnosed anaplastic oligoastrocytoma patients were enrolled (median age of 41 years, range 19-63; median Karnofsky performance status of 90, range 70-100). All patients were treated with Cisplatin (109 mg/m2) and BCNU (160 mg/m2). The chemotherapy started in the first week after surgery and it was administered every 6 weeks (5 scheduled cycles) for a total of 127 cycles. After the second cycle of chemotherapy all patients received radiotherapy (56.5 Gy). The median follow-up was 63.2 months (10-91). Nine patients were reoperated-on. The median time to tumor progression (TTP) and median survival time (ST) for the whole group of patients were 54.6 and 70.1 months, respectively. A proportional hazard model was used to look at potential prognostic factors for survival including lower age (<40 years), extent of surgery (total/subtotal versus partial) and reoperation. When we analyzed the group of patients with total/subtotal surgery or age under 40 years the median ST could not be assessed due to the high number of surviving patients after a follow-up of 52 months. The median ST for the older patients or for patients partially operated-on was 54.1 and 42.2 months. In our study only total/subtotal surgery predicted for longer survival (p <0.001). This schedule of treatment provides durable response in a selected group of anaplastic oligoastrocytoma patients.
Original language | English |
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Pages (from-to) | 71-75 |
Number of pages | 5 |
Journal | Journal of Neuro-Oncology |
Volume | 49 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- Anaplastic astrocytoma
- BCNU
- Chemotherapy
- Cisplatinum
- Mixed gliomas
ASJC Scopus subject areas
- Cancer Research
- Clinical Neurology
- Oncology
- Neuroscience(all)