Cisplatin and etoposide as second-line chemotherapy in patients with small cell lung cancer

Franco Figoli, Andrea Veronesi, Andrea Ardizzoni, Luciano Canobbio, Gioia Bruschi, Francesco Mazza, Vittorina Zagonel, Giovanni Lo Re, Riccardo Rosso, Silvio Monfardini

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Abstract

Twenty-seven evaluable patients with small cell lung cancer (SCLC) resistant to, or relapsed after induction combination chemotherapy (CT) were treated with etoposide (VPJ6) plus cisplatin (DDP). Previous treatment was: alternating CT with cyclophosphamide (C), adriamycin (A), methotrexate (M), procarbazine (P) (CAMP)/VP16, BCNU (B), hexamethylmelamine (H) (VP16BH) in 16 patients; C, A, vincristine (CAV) in 6 patients; C, A, and VP16 (CAVP16) in 5 patients. We observed 2 (7% complete responses (CR) and 9 (33% partial responses (PR). Duration of CRs was 8 and 14 weeks, respectively. PRs lasted a median of 22 weeks (range 16-44). Seven of 21 (33% patients previously treated with VP16 responded to DDP plus VP16 (D-V). These results confirm D-V regimen as active in SCLC patients even when heavily pretreated. Our 33 % response in patients who had VP16 in their induction treatment regimen provides further evidence of an important potentiating effect of DDP, as reported in animal system.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCancer Investigation
Volume6
Issue number1
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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