Cisplatin and etoposide (VP-16) as a single regimen for small cell lung cancer. A phase II trial

C. Boni, G. Cocconi, G. Bisagni, G. Ceci, G. Peracchia

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Abstract

Forty-seven consecutive patients with small cell lung cancer (SCLC) were treated with a combination chemotherapy program including 60 mg/m2 of cisplatin (P) on day 1 and 120 mg/m2 of etoposide (E) on day 4, 6, 8, every 21 days. Limited disease (LD) patients, achieving complete response (CR) or partial response (PR) after the three initial courses, received radiotherapy (RT) to the pretreatment primary tumor volume and, those achieving CR, additional RT to the brain. During RT, chemotherapy was administered with 50% dose reduction. Forty-three patients were evaluable for therapeutic response. In the 19 patients with LD, CR was achieved in 63% of patients and the PR rate was 32%. In 24 patients with extensive disease (ED), CR was 34% and PR rate was 54%. Median duration of survival was 66 weeks for LD and 48 weeks for ED. Six patients were disease-free after 2 years. Leucocyte count 3 was seen in 26% of patients; platelet count 3 was observed in 9%. Nonhematologic toxicity included universal nausea or vomiting and severe neurotoxicity in 7%. These data indicate that PE combination is a very active front-line regimen in SCLC and could be suggested as one of the reference treatments.

Original languageEnglish
Pages (from-to)638-642
Number of pages5
JournalCancer
Volume63
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Boni, C., Cocconi, G., Bisagni, G., Ceci, G., & Peracchia, G. (1989). Cisplatin and etoposide (VP-16) as a single regimen for small cell lung cancer. A phase II trial. Cancer, 63(4), 638-642.