Citalopram in refractory obsessive - Compulsive disorder: An open study

D. Marazziti, L. Dell'Osso, A. Gemignani, A. Ciapparelli, S. Presta, E. Di Nasso, C. Pfanner, G. B. Cassano

Research output: Contribution to journalArticle

Abstract

This study aimed to evaluate the effect of citalopram in patients with refractory obsessive-compulsive disorder (OCD) which had not responded to previous antiobsessional treatments. Eighteen patients were selected for this study: they had been suffering from OCD, according to DSM-IV criteria, for at least 2 years and had various comorbid disorders. All had been treated with serotonin reuptake inhibitors at adequate dosages for at least 6 months, but had failed to respond. Consequently, they were shifted to citalopram, titrated up to the dose of 40 mg, within 2 weeks. After 4 months of this regimen, 14 out of the total of 18 patients had shown a reduction in OC symptoms, as assessed by the decrease in the Yale-Brown Obsessive Compulsive Scale total score; no relevant side-effects were reported, except for a mild nausea in four patients within the first few days of treatment, which quickly disappeared. The use of citalopram would appear to be an useful strategy in refractory OCD cases.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalInternational Clinical Psychopharmacology
Volume16
Issue number4
Publication statusPublished - 2001

Fingerprint

Citalopram
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Diagnostic and Statistical Manual of Mental Disorders
Nausea
Therapeutics

Keywords

  • Augmentation strategies
  • Citalopram
  • Obsessive-compulsive disorder
  • Serotonin reuptake inhibitors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Marazziti, D., Dell'Osso, L., Gemignani, A., Ciapparelli, A., Presta, S., Di Nasso, E., ... Cassano, G. B. (2001). Citalopram in refractory obsessive - Compulsive disorder: An open study. International Clinical Psychopharmacology, 16(4), 215-219.

Citalopram in refractory obsessive - Compulsive disorder : An open study. / Marazziti, D.; Dell'Osso, L.; Gemignani, A.; Ciapparelli, A.; Presta, S.; Di Nasso, E.; Pfanner, C.; Cassano, G. B.

In: International Clinical Psychopharmacology, Vol. 16, No. 4, 2001, p. 215-219.

Research output: Contribution to journalArticle

Marazziti, D, Dell'Osso, L, Gemignani, A, Ciapparelli, A, Presta, S, Di Nasso, E, Pfanner, C & Cassano, GB 2001, 'Citalopram in refractory obsessive - Compulsive disorder: An open study', International Clinical Psychopharmacology, vol. 16, no. 4, pp. 215-219.
Marazziti D, Dell'Osso L, Gemignani A, Ciapparelli A, Presta S, Di Nasso E et al. Citalopram in refractory obsessive - Compulsive disorder: An open study. International Clinical Psychopharmacology. 2001;16(4):215-219.
Marazziti, D. ; Dell'Osso, L. ; Gemignani, A. ; Ciapparelli, A. ; Presta, S. ; Di Nasso, E. ; Pfanner, C. ; Cassano, G. B. / Citalopram in refractory obsessive - Compulsive disorder : An open study. In: International Clinical Psychopharmacology. 2001 ; Vol. 16, No. 4. pp. 215-219.
@article{7d48ed2459044f1081ce14c995ef762e,
title = "Citalopram in refractory obsessive - Compulsive disorder: An open study",
abstract = "This study aimed to evaluate the effect of citalopram in patients with refractory obsessive-compulsive disorder (OCD) which had not responded to previous antiobsessional treatments. Eighteen patients were selected for this study: they had been suffering from OCD, according to DSM-IV criteria, for at least 2 years and had various comorbid disorders. All had been treated with serotonin reuptake inhibitors at adequate dosages for at least 6 months, but had failed to respond. Consequently, they were shifted to citalopram, titrated up to the dose of 40 mg, within 2 weeks. After 4 months of this regimen, 14 out of the total of 18 patients had shown a reduction in OC symptoms, as assessed by the decrease in the Yale-Brown Obsessive Compulsive Scale total score; no relevant side-effects were reported, except for a mild nausea in four patients within the first few days of treatment, which quickly disappeared. The use of citalopram would appear to be an useful strategy in refractory OCD cases.",
keywords = "Augmentation strategies, Citalopram, Obsessive-compulsive disorder, Serotonin reuptake inhibitors",
author = "D. Marazziti and L. Dell'Osso and A. Gemignani and A. Ciapparelli and S. Presta and {Di Nasso}, E. and C. Pfanner and Cassano, {G. B.}",
year = "2001",
language = "English",
volume = "16",
pages = "215--219",
journal = "International Clinical Psychopharmacology",
issn = "0268-1315",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Citalopram in refractory obsessive - Compulsive disorder

T2 - An open study

AU - Marazziti, D.

AU - Dell'Osso, L.

AU - Gemignani, A.

AU - Ciapparelli, A.

AU - Presta, S.

AU - Di Nasso, E.

AU - Pfanner, C.

AU - Cassano, G. B.

PY - 2001

Y1 - 2001

N2 - This study aimed to evaluate the effect of citalopram in patients with refractory obsessive-compulsive disorder (OCD) which had not responded to previous antiobsessional treatments. Eighteen patients were selected for this study: they had been suffering from OCD, according to DSM-IV criteria, for at least 2 years and had various comorbid disorders. All had been treated with serotonin reuptake inhibitors at adequate dosages for at least 6 months, but had failed to respond. Consequently, they were shifted to citalopram, titrated up to the dose of 40 mg, within 2 weeks. After 4 months of this regimen, 14 out of the total of 18 patients had shown a reduction in OC symptoms, as assessed by the decrease in the Yale-Brown Obsessive Compulsive Scale total score; no relevant side-effects were reported, except for a mild nausea in four patients within the first few days of treatment, which quickly disappeared. The use of citalopram would appear to be an useful strategy in refractory OCD cases.

AB - This study aimed to evaluate the effect of citalopram in patients with refractory obsessive-compulsive disorder (OCD) which had not responded to previous antiobsessional treatments. Eighteen patients were selected for this study: they had been suffering from OCD, according to DSM-IV criteria, for at least 2 years and had various comorbid disorders. All had been treated with serotonin reuptake inhibitors at adequate dosages for at least 6 months, but had failed to respond. Consequently, they were shifted to citalopram, titrated up to the dose of 40 mg, within 2 weeks. After 4 months of this regimen, 14 out of the total of 18 patients had shown a reduction in OC symptoms, as assessed by the decrease in the Yale-Brown Obsessive Compulsive Scale total score; no relevant side-effects were reported, except for a mild nausea in four patients within the first few days of treatment, which quickly disappeared. The use of citalopram would appear to be an useful strategy in refractory OCD cases.

KW - Augmentation strategies

KW - Citalopram

KW - Obsessive-compulsive disorder

KW - Serotonin reuptake inhibitors

UR - http://www.scopus.com/inward/record.url?scp=0034957597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034957597&partnerID=8YFLogxK

M3 - Article

C2 - 11459335

AN - SCOPUS:0034957597

VL - 16

SP - 215

EP - 219

JO - International Clinical Psychopharmacology

JF - International Clinical Psychopharmacology

SN - 0268-1315

IS - 4

ER -