Citicoline oral solution in glaucoma: Is there a role in slowing disease progression?

L. Ottobelli, G. L. Manni, M. Centofanti, M. Iester, F. Allevena, L. Rossetti

Research output: Contribution to journalArticlepeer-review


Purpose: To assess the effect of citicoline on visual field rates of progression in patients with progressing glaucoma. Patients and Methods: Forty-one patients with a diagnosis of progressing glaucoma received citicoline in oral solution for 2 years. Included were patients with a disease progression of at least -1 dB/year (at MD, mean deviation) for at least 3 years before entering the study despite controlled intraocular pressure (IOP). Patients were followed with 4 visual field examinations per year for 2 years. Results: At baseline, the mean rate of progression was -1.1 (±0.7) dB/year despite the fact that the IOP had been below 18 mm Hg for at least 3 years. At study inclusion, the mean IOP was 15.5 (±2.6) mm Hg and the mean MD was -9.2 (±6.7) dB in the worst eye. Starting from the first cycle of treatment with citicoline, the mean rate of progression significantly changed to -0.15 (±0.3) dB/year at the end of the study (p = 0.01). Conclusions: This study seems to indicate that supplementation with citicoline might significantly slow down glaucomatous rates of progression.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
Issue number4
Publication statusPublished - May 2013


  • Citicoline
  • Glaucoma
  • Visual field rate of progression

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Medicine(all)

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