Abstract
Two chromosome-encoded beta-lactamases have been purified from Citrobacter diversus ULA-27. They exhibited slightly different isoelectric points (6.8 and 6.2) and very similar Mr values (congruent to 29,000). Their specificity spectrum was rather wide, since they hydrolysed some cephalosporins with kcat: values similar to those observed with the best penicillin substrates. Cloxacillin, methicillin and imipenem were hydrolysed very slowly. Hydrolysis of azthreonam could not be detected.
Original language | English |
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Pages (from-to) | 885-890 |
Number of pages | 6 |
Journal | Biochemical Journal |
Volume | 254 |
Issue number | 3 |
Publication status | Published - Sep 15 1988 |
ASJC Scopus subject areas
- Biochemistry