TY - JOUR
T1 - Citrus fruit and cancer risk in a network of case-control studies
AU - Foschi, Roberto
AU - Pelucchi, Claudio
AU - Dal Maso, Luigino
AU - Rossi, Marta
AU - Levi, Fábio
AU - Talamini, Renato
AU - Bosetti, Cristina
AU - Negri, Eva
AU - Serraino, Diego
AU - Giacosa, Attilio
AU - Franceschi, Silvia
AU - La Vecchia, Carlo
PY - 2010/2
Y1 - 2010/2
N2 - Background Citrus fruit has shown a favorable effect against various cancers. To better understand their role in cancer risk, we analyzed data from a series of case-control studies conducted in Italy and Switzerland. Patients and methods The studies included 955 patients with oral and pharyngeal cancer, 395 with esophageal, 999 with stomach, 3,634 with large bowel, 527 with laryngeal, 2,900 with breast, 454 with endometrial, 1,031 with ovarian, 1,294 with prostate, and 767 with renal cell cancer. All cancers were incident and histologically confirmed. Controls were admitted to the same network of hospitals for acute, nonneoplastic conditions. Odds ratios (OR) were estimated by multiple logistic regression models, including terms for major identified confounding factors for each cancer site, and energy intake. Results The ORs for the highest versus lowest category of citrus fruit consumption were 0.47 (95% confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI, 0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95% CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal cancer. No consistent association was found with breast, endometrial, ovarian, prostate, and renal cell cancer. Conclusions Our findings indicate that citrus fruit has a protective role against cancers of the digestive and upper respiratory tract.
AB - Background Citrus fruit has shown a favorable effect against various cancers. To better understand their role in cancer risk, we analyzed data from a series of case-control studies conducted in Italy and Switzerland. Patients and methods The studies included 955 patients with oral and pharyngeal cancer, 395 with esophageal, 999 with stomach, 3,634 with large bowel, 527 with laryngeal, 2,900 with breast, 454 with endometrial, 1,031 with ovarian, 1,294 with prostate, and 767 with renal cell cancer. All cancers were incident and histologically confirmed. Controls were admitted to the same network of hospitals for acute, nonneoplastic conditions. Odds ratios (OR) were estimated by multiple logistic regression models, including terms for major identified confounding factors for each cancer site, and energy intake. Results The ORs for the highest versus lowest category of citrus fruit consumption were 0.47 (95% confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI, 0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95% CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal cancer. No consistent association was found with breast, endometrial, ovarian, prostate, and renal cell cancer. Conclusions Our findings indicate that citrus fruit has a protective role against cancers of the digestive and upper respiratory tract.
KW - Citrus
KW - Epidemiology
KW - Neoplasms
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=77950691556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950691556&partnerID=8YFLogxK
U2 - 10.1007/s10552-009-9454-4
DO - 10.1007/s10552-009-9454-4
M3 - Article
C2 - 19856118
AN - SCOPUS:77950691556
VL - 21
SP - 237
EP - 242
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 2
ER -