Citrus fruit intake and gastric cancer

The stomach cancer pooling (StoP) project consortium

Paola Bertuccio, Gianfranco Alicandro, Matteo Rota, Claudio Pelucchi, Rossella Bonzi, Carlotta Galeone, Francesca Bravi, Kenneth C Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Lizbeth López-Carrillo, Nuno Lunet, Ana Ferro, Reza Malekzadeh, David Zaridze, Dmitry Maximovitch, Jesus Vioque, Eva M Navarrete-Munoz, Mohammadreza Pakseresht & 14 others Raúl U Hernández-Ramírez, Malaquias López-Cervantes, Mary Ward, Farhad Pourfarzi, Shoichiro Tsugane, Akihisa Hidaka, Zuo-Feng Zhang, Robert C Kurtz, Pagona Lagiou, Areti Lagiou, Paolo Boffetta, Stefania Boccia, Eva Negri, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. Our study aimed at evaluating and quantifying the association between citrus fruit intake and gastric cancer risk. We conducted a one-stage pooled analysis including 6,340 cases and 14,490 controls from 15 case-control studies from the stomach cancer pooling (StoP) project consortium. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer across study-specific tertiles of citrus fruit intake (grams/week) were estimated by generalized linear mixed effect models, with logistic link function and random intercept for each study. The models were adjusted for sex, age, and the main recognized risk factors for gastric cancer. Compared to the first third of the distribution, the adjusted pooled OR (95% CI) for the highest third was 0.80 (0.73-0.87). The favourable effect of citrus fruits increased progressively until three servings/week and leveled off thereafter. The magnitude of the association was similar between cancer sub-sites and histotypes. The analysis by geographic area showed no association in studies from the Americas. Our data confirm an inverse association between citrus fruits and gastric cancer and provide precise estimates of the magnitude of the association. However, the null association found in studies from America and in some previous cohort studies prevent to draw definite conclusions on a protective effect of citrus fruit consumption.

Original languageEnglish
JournalInternational Journal of Cancer
DOIs
Publication statusE-pub ahead of print - Dec 6 2018

Fingerprint

Citrus
Stomach Neoplasms
Odds Ratio
Confidence Intervals
Vegetables
Case-Control Studies
Fruit
Cohort Studies
Logistic Models
Diet
Neoplasms

Cite this

Bertuccio, P., Alicandro, G., Rota, M., Pelucchi, C., Bonzi, R., Galeone, C., ... La Vecchia, C. (2018). Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium. International Journal of Cancer. https://doi.org/10.1002/ijc.32046

Citrus fruit intake and gastric cancer : The stomach cancer pooling (StoP) project consortium. / Bertuccio, Paola; Alicandro, Gianfranco; Rota, Matteo; Pelucchi, Claudio; Bonzi, Rossella; Galeone, Carlotta; Bravi, Francesca; Johnson, Kenneth C; Hu, Jinfu; Palli, Domenico; Ferraroni, Monica; López-Carrillo, Lizbeth; Lunet, Nuno; Ferro, Ana; Malekzadeh, Reza; Zaridze, David; Maximovitch, Dmitry; Vioque, Jesus; Navarrete-Munoz, Eva M; Pakseresht, Mohammadreza; Hernández-Ramírez, Raúl U; López-Cervantes, Malaquias; Ward, Mary; Pourfarzi, Farhad; Tsugane, Shoichiro; Hidaka, Akihisa; Zhang, Zuo-Feng; Kurtz, Robert C; Lagiou, Pagona; Lagiou, Areti; Boffetta, Paolo; Boccia, Stefania; Negri, Eva; La Vecchia, Carlo.

In: International Journal of Cancer, 06.12.2018.

Research output: Contribution to journalArticle

Bertuccio, P, Alicandro, G, Rota, M, Pelucchi, C, Bonzi, R, Galeone, C, Bravi, F, Johnson, KC, Hu, J, Palli, D, Ferraroni, M, López-Carrillo, L, Lunet, N, Ferro, A, Malekzadeh, R, Zaridze, D, Maximovitch, D, Vioque, J, Navarrete-Munoz, EM, Pakseresht, M, Hernández-Ramírez, RU, López-Cervantes, M, Ward, M, Pourfarzi, F, Tsugane, S, Hidaka, A, Zhang, Z-F, Kurtz, RC, Lagiou, P, Lagiou, A, Boffetta, P, Boccia, S, Negri, E & La Vecchia, C 2018, 'Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium', International Journal of Cancer. https://doi.org/10.1002/ijc.32046
Bertuccio, Paola ; Alicandro, Gianfranco ; Rota, Matteo ; Pelucchi, Claudio ; Bonzi, Rossella ; Galeone, Carlotta ; Bravi, Francesca ; Johnson, Kenneth C ; Hu, Jinfu ; Palli, Domenico ; Ferraroni, Monica ; López-Carrillo, Lizbeth ; Lunet, Nuno ; Ferro, Ana ; Malekzadeh, Reza ; Zaridze, David ; Maximovitch, Dmitry ; Vioque, Jesus ; Navarrete-Munoz, Eva M ; Pakseresht, Mohammadreza ; Hernández-Ramírez, Raúl U ; López-Cervantes, Malaquias ; Ward, Mary ; Pourfarzi, Farhad ; Tsugane, Shoichiro ; Hidaka, Akihisa ; Zhang, Zuo-Feng ; Kurtz, Robert C ; Lagiou, Pagona ; Lagiou, Areti ; Boffetta, Paolo ; Boccia, Stefania ; Negri, Eva ; La Vecchia, Carlo. / Citrus fruit intake and gastric cancer : The stomach cancer pooling (StoP) project consortium. In: International Journal of Cancer. 2018.
@article{fe18cfeaf8e043b8afb71d4208ee7c79,
title = "Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium",
abstract = "Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. Our study aimed at evaluating and quantifying the association between citrus fruit intake and gastric cancer risk. We conducted a one-stage pooled analysis including 6,340 cases and 14,490 controls from 15 case-control studies from the stomach cancer pooling (StoP) project consortium. Odds ratios (ORs) and the corresponding 95{\%} confidence intervals (CIs) of gastric cancer across study-specific tertiles of citrus fruit intake (grams/week) were estimated by generalized linear mixed effect models, with logistic link function and random intercept for each study. The models were adjusted for sex, age, and the main recognized risk factors for gastric cancer. Compared to the first third of the distribution, the adjusted pooled OR (95{\%} CI) for the highest third was 0.80 (0.73-0.87). The favourable effect of citrus fruits increased progressively until three servings/week and leveled off thereafter. The magnitude of the association was similar between cancer sub-sites and histotypes. The analysis by geographic area showed no association in studies from the Americas. Our data confirm an inverse association between citrus fruits and gastric cancer and provide precise estimates of the magnitude of the association. However, the null association found in studies from America and in some previous cohort studies prevent to draw definite conclusions on a protective effect of citrus fruit consumption.",
author = "Paola Bertuccio and Gianfranco Alicandro and Matteo Rota and Claudio Pelucchi and Rossella Bonzi and Carlotta Galeone and Francesca Bravi and Johnson, {Kenneth C} and Jinfu Hu and Domenico Palli and Monica Ferraroni and Lizbeth L{\'o}pez-Carrillo and Nuno Lunet and Ana Ferro and Reza Malekzadeh and David Zaridze and Dmitry Maximovitch and Jesus Vioque and Navarrete-Munoz, {Eva M} and Mohammadreza Pakseresht and Hern{\'a}ndez-Ram{\'i}rez, {Ra{\'u}l U} and Malaquias L{\'o}pez-Cervantes and Mary Ward and Farhad Pourfarzi and Shoichiro Tsugane and Akihisa Hidaka and Zuo-Feng Zhang and Kurtz, {Robert C} and Pagona Lagiou and Areti Lagiou and Paolo Boffetta and Stefania Boccia and Eva Negri and {La Vecchia}, Carlo",
note = "{\circledC} 2018 UICC.",
year = "2018",
month = "12",
day = "6",
doi = "10.1002/ijc.32046",
language = "English",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Citrus fruit intake and gastric cancer

T2 - The stomach cancer pooling (StoP) project consortium

AU - Bertuccio, Paola

AU - Alicandro, Gianfranco

AU - Rota, Matteo

AU - Pelucchi, Claudio

AU - Bonzi, Rossella

AU - Galeone, Carlotta

AU - Bravi, Francesca

AU - Johnson, Kenneth C

AU - Hu, Jinfu

AU - Palli, Domenico

AU - Ferraroni, Monica

AU - López-Carrillo, Lizbeth

AU - Lunet, Nuno

AU - Ferro, Ana

AU - Malekzadeh, Reza

AU - Zaridze, David

AU - Maximovitch, Dmitry

AU - Vioque, Jesus

AU - Navarrete-Munoz, Eva M

AU - Pakseresht, Mohammadreza

AU - Hernández-Ramírez, Raúl U

AU - López-Cervantes, Malaquias

AU - Ward, Mary

AU - Pourfarzi, Farhad

AU - Tsugane, Shoichiro

AU - Hidaka, Akihisa

AU - Zhang, Zuo-Feng

AU - Kurtz, Robert C

AU - Lagiou, Pagona

AU - Lagiou, Areti

AU - Boffetta, Paolo

AU - Boccia, Stefania

AU - Negri, Eva

AU - La Vecchia, Carlo

N1 - © 2018 UICC.

PY - 2018/12/6

Y1 - 2018/12/6

N2 - Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. Our study aimed at evaluating and quantifying the association between citrus fruit intake and gastric cancer risk. We conducted a one-stage pooled analysis including 6,340 cases and 14,490 controls from 15 case-control studies from the stomach cancer pooling (StoP) project consortium. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer across study-specific tertiles of citrus fruit intake (grams/week) were estimated by generalized linear mixed effect models, with logistic link function and random intercept for each study. The models were adjusted for sex, age, and the main recognized risk factors for gastric cancer. Compared to the first third of the distribution, the adjusted pooled OR (95% CI) for the highest third was 0.80 (0.73-0.87). The favourable effect of citrus fruits increased progressively until three servings/week and leveled off thereafter. The magnitude of the association was similar between cancer sub-sites and histotypes. The analysis by geographic area showed no association in studies from the Americas. Our data confirm an inverse association between citrus fruits and gastric cancer and provide precise estimates of the magnitude of the association. However, the null association found in studies from America and in some previous cohort studies prevent to draw definite conclusions on a protective effect of citrus fruit consumption.

AB - Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. Our study aimed at evaluating and quantifying the association between citrus fruit intake and gastric cancer risk. We conducted a one-stage pooled analysis including 6,340 cases and 14,490 controls from 15 case-control studies from the stomach cancer pooling (StoP) project consortium. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer across study-specific tertiles of citrus fruit intake (grams/week) were estimated by generalized linear mixed effect models, with logistic link function and random intercept for each study. The models were adjusted for sex, age, and the main recognized risk factors for gastric cancer. Compared to the first third of the distribution, the adjusted pooled OR (95% CI) for the highest third was 0.80 (0.73-0.87). The favourable effect of citrus fruits increased progressively until three servings/week and leveled off thereafter. The magnitude of the association was similar between cancer sub-sites and histotypes. The analysis by geographic area showed no association in studies from the Americas. Our data confirm an inverse association between citrus fruits and gastric cancer and provide precise estimates of the magnitude of the association. However, the null association found in studies from America and in some previous cohort studies prevent to draw definite conclusions on a protective effect of citrus fruit consumption.

U2 - 10.1002/ijc.32046

DO - 10.1002/ijc.32046

M3 - Article

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

ER -