Clarithromycin-carbamazepine interaction: A case report

F. Albani, R. Riva, A. Baruzzi, P. Genton, A. Portera-Sanchez, C. G. Lipinski

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin, and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10-day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ-E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.

Original languageEnglish
Pages (from-to)161-162
Number of pages2
JournalEpilepsia
Volume34
Issue number1
DOIs
Publication statusPublished - 1993

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Clarithromycin
Carbamazepine
Anti-Bacterial Agents
Macrolides

Keywords

  • Anticonvulsants
  • Carbamazepine
  • Carbamazepine-epoxide
  • Clarithromycin
  • Drug interactions
  • Drug toxicity
  • Macrolide antibiotics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Albani, F., Riva, R., Baruzzi, A., Genton, P., Portera-Sanchez, A., & Lipinski, C. G. (1993). Clarithromycin-carbamazepine interaction: A case report. Epilepsia, 34(1), 161-162. https://doi.org/10.1111/j.1528-1157.1993.tb02391.x

Clarithromycin-carbamazepine interaction : A case report. / Albani, F.; Riva, R.; Baruzzi, A.; Genton, P.; Portera-Sanchez, A.; Lipinski, C. G.

In: Epilepsia, Vol. 34, No. 1, 1993, p. 161-162.

Research output: Contribution to journalArticle

Albani, F, Riva, R, Baruzzi, A, Genton, P, Portera-Sanchez, A & Lipinski, CG 1993, 'Clarithromycin-carbamazepine interaction: A case report', Epilepsia, vol. 34, no. 1, pp. 161-162. https://doi.org/10.1111/j.1528-1157.1993.tb02391.x
Albani F, Riva R, Baruzzi A, Genton P, Portera-Sanchez A, Lipinski CG. Clarithromycin-carbamazepine interaction: A case report. Epilepsia. 1993;34(1):161-162. https://doi.org/10.1111/j.1528-1157.1993.tb02391.x
Albani, F. ; Riva, R. ; Baruzzi, A. ; Genton, P. ; Portera-Sanchez, A. ; Lipinski, C. G. / Clarithromycin-carbamazepine interaction : A case report. In: Epilepsia. 1993 ; Vol. 34, No. 1. pp. 161-162.
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