Clarithromycin-carbamazepine interaction: A case report

F. Albani, R. Riva, A. Baruzzi, P. Genton, A. Portera-Sanchez, C. G. Lipinski

Research output: Contribution to journalArticle

Abstract

We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin, and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10-day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ-E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.

Original languageEnglish
Pages (from-to)161-162
Number of pages2
JournalEpilepsia
Volume34
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • Anticonvulsants
  • Carbamazepine
  • Carbamazepine-epoxide
  • Clarithromycin
  • Drug interactions
  • Drug toxicity
  • Macrolide antibiotics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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  • Cite this

    Albani, F., Riva, R., Baruzzi, A., Genton, P., Portera-Sanchez, A., & Lipinski, C. G. (1993). Clarithromycin-carbamazepine interaction: A case report. Epilepsia, 34(1), 161-162. https://doi.org/10.1111/j.1528-1157.1993.tb02391.x