Class II versus Class III radical hysterectomy in early cervical cancer: An observational study in a tertiary center

A. Ditto, F. Martinelli, S. Ramondino, S. L. Vullo, M. Carcangiu, E. Haeusler, L. Mariani, D. Lorusso, F. Raspagliesi

Research output: Contribution to journalArticlepeer-review


Aims The purpose of this observational study was to evaluate disease free survival (DFS), overall survival (OS), and local recurrence rate (LRR) in patients submitted to Class II RH compared with Class III RH in early FIGO stage cervical cancer (ECC). Materials and methods We investigated 127 patients with CC admitted to the National Cancer Institute of Milan from June 2001 to October 2011 treated with Class II RH, and compared them with 202 patients operated with Class III RH between March 1980 and March 2001. A total of 329 patients were collected. Results Median follow-up time was 91 months (IQ range:58-196). Five-year OS and DFS estimates were 89.5% (95%CI: 86.0-93.2%) and 85.6% (95%CI: 81.6-89.7%), respectively. Estimates of effect of surgical treatment (Class III RH versus Class II RH) on OS showed a HR of death = 3.38 (95%CI: 1.18-9.63, P = 0.0228), at univariable Cox analysis, and a HR = 3.08 (95%CI: 0.96-9.93; P = 0.0595) at multivariable analysis. For DFS, a HR of relapse = 2.51 (95%CI 1.10-5.72; P = 0.0290) comparing Class III vs Class II was found at multivariable analysis. Overall recurrence rate was 12.8%, whilst it was 16.3% for Class III and 7.1% for Class II respectively. Conclusions The present data suggest that the outcomes of Class II RH are comparable in terms of LRR and OS to those of Class III RH, according to literature data. The opportunity of extending the indication to all women with ECC needs further investigations. Clearer data are warranted by prospective controlled studies.

Original languageEnglish
Pages (from-to)883-890
Number of pages8
JournalEuropean Journal of Surgical Oncology
Issue number7
Publication statusPublished - 2014


  • Cervical cancer
  • Overall/disease free survival
  • Radical hysterectomy
  • Recurrence rate
  • Tailoring radicality

ASJC Scopus subject areas

  • Oncology
  • Surgery


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