Classic migraine and intercalated seizures in a young woman: Efficacy of flunarizine

M. C. Narbone, D. D'Amico, R. Di Perri

Research output: Chapter in Book/Report/Conference proceedingChapter


A case of a young woman suffering from both migraine and epilepsy is reported. Since the age of 28, she complained of classic migraine attacks and of generalized or partial seizures. The seizures often intercalated themselves between the visual prodrome and the painful phase of her attacks. She came to our observation at the age of 31. Neurological examination, laboratory work and CT-scan were normal. The EEG showed an asymmetry of the background activity between the two hemispheres and medium-voltage sharp waves, not blocking upon eye opening, in the left parieto-temporal leads. Flunarizine was added to her anti-convulsant therapy. It remarkably reduced the migraine attacks and controlled the intercalated seizures. After one year, flunarizine was discontinued and two intercalated seizures occurred four months later. The efficacy of flunarizine and its hypothetical mechanism of action in such a clinical condition is discussed.

Original languageEnglish
Title of host publicationHeadache
Number of pages3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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